1551022-64-0Relevant academic research and scientific papers
Intramolecular Stereoselective Stetter Reaction Catalyzed by Benzaldehyde Lyase
Chen, Xiaoyang,Wang, Zhiguo,Lou, Yujiao,Peng, Yongzhen,Zhu, Qiaoyan,Xu, Jian,Wu, Qi
, p. 9326 - 9329 (2021)
The reliable design and prediction of enzyme promiscuity to access transformations not observed in nature remains a long-standing challenge. Herein, we present the first example of an intramolecular stereoselective Stetter reaction catalyzed by benzaldehyde lyase, guided by the rational structure screening of various ThDP-dependent enzymes using molecular dynamics (MD) simulations. After optimization, high productivity (up to 99 %) and stereoselectivity (up to 99:1 e.r.) for this novel enzyme function was achieved.
Constrained TRPV1 agonists synthesized via silver-mediated intramolecular azo-methine ylide cycloaddition of α-iminoamides
Painter, Thomas O.,Kaszas, Krisztian,Gross, Jacklyn,Douglas, Justin T.,Day, Victor W.,Iadarola, Michael J.,Santini, Conrad
, p. 963 - 968 (2014/02/14)
As part of an effort to identify agonists of TRPV1, a peripheral sensory nerve ion channel, high throughput screening of the NIH Small Molecule Repository (SMR) collection identified MLS002174161, a pentacyclic benzodiazepine. A synthesis effort was initi
