1551093-24-3Relevant academic research and scientific papers
Enantioselective organocatalytic oxa-Michael addition of oximes to β-CF3-β-disubstituted nitroalkenes: Efficient synthesis of β-amino-α-trifluoromethyl alcohols
Liu, Feng-Lei,Chen, Jia-Rong,Feng, Bin,Hu, Xiao-Qiang,Ye, Li-Hua,Lu, Liang-Qiu,Xiao, Wen-Jing
supporting information, p. 1057 - 1060 (2014/02/14)
An enantioselective oxa-Michael addition of oximes to β-CF 3-β-disubstituted nitroalkenes catalyzed by a chiral bifunctional cinchona alkaloid-based thiourea has been developed. A variety of trifluoromethylated oxime ethers possessing a tetrasubstituted carbon stereocenter were obtained in good yields with high enantioselectivities. The Royal Society of Chemistry.
