15540-79-1Relevant academic research and scientific papers
Industrial production of the isophthalic acid derivatives
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Paragraph 0019; 0036-0044, (2020/05/08)
The invention discloses an industrial production method of a compound represented by the formula I. The method comprises the following steps: taking p-aminosalicylic acid, potassium salts, and carbon dioxide as the raw materials, and carrying out reactions in melted potassium formate so as to introduce carboxyl groups into a multi-substituted benzene ring under mild conditions. Compared to the prior art, the provided method is carried out under a normal pressure, thus the production operation is safe, furthermore, pricy high-pressure reactor is not required, and the cost is reduced. While the reaction pressure is reduced, the reaction time is not increased, and the reaction time is greatly reduced instead.
