15547-41-8

Basic information

• Product Name: (+)-3,4-Dihydro-3-methylisoquinoline
• Synonyms: Isoquinoline, 3,4-dihydro-3-methyl-, (3R)-
• CAS NO: 15547-41-8
• Molecular Formula: C10H11N
• Molecular Weight: 145.2
• Mol File: 15547-41-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (+)-3,4-Dihydro-3-methylisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-3,4-Dihydro-3-methylisoquinoline(15547-41-8)
• EPA Substance Registry System: (+)-3,4-Dihydro-3-methylisoquinoline(15547-41-8)

Safety Data

• Hazardous Substances Data: 15547-41-8(Hazardous Substances Data)

Upstream product

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Relevant articles and documents

Chiral DNA gyrase inhibitors. 3. Probing the chiral preference of the active site of DNA gyrase. Synthesis of 10-fluoro-6-methyl-6,7-dihydro-9- piperazinyl-2H-benzo[a]quinolizin-20-one-3-carboxylic acid analogues

In pursuit of an apparent literature anomaly, S- and R-6-methyl-6,7- dihydro-2H-benzo[a]-quinolizin-2-one-3-carboxylic acids (12 and 22) were synthesized by an unambiguous route from optically active norephedrines, and their antibacterial potencies were measured. Against Gram-negative microorganisms and DNA gyrase a preference for S-absolute configuration was found whereas R-absolute stereochemistry was more active against Gram-positives. These results are in partial conflict with an earlier report. In an attempt to enhance potency, racemic 10-fluoro-9-piperazinyl (35) and related analogues were synthesized by a novel route. The latter analogues were surprisingly unimproved in potency. The implications of these findings are briefly discussed.