155505-55-8

Upstream product

• 68858-21-9 [4-(hydroxymethyl)phenoxy]acetic acid 
• 106-95-6 allyl bromide 
• 123-08-0 4-hydroxy-benzaldehyde 
• 2916-14-5 allyl chloroacetate 
• 226250-40-4 4-formylphenoxyallylacetate 

Downstream Products

• 192064-31-6 4-nitrophenyl-4'-hydroxymethylphenyl-1'-oxyallylacetate carbonate 
• 400648-91-1 4-[3-(4-bromophenyl)-2-(4-methoxy-3-nitrophenyl)propionyloxymethyl]phenoxyacetic acid allyl ester 
• 313983-92-5 [4-({[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid allyl ester 
• 313983-90-3 [4-({bis-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid allyl ester 
• 313983-98-1 [4-({[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid 
• 313983-96-9 [4-({bis-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid 
• 213008-45-8 [4-({(4-{tert-Butoxycarbonyl-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-amino}-butyl)-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid allyl ester 
• 213008-46-9 [4-({(4-{tert-Butoxycarbonyl-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-amino}-butyl)-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid 
• 874180-66-2 2-[3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methoxy-phenyl]-3-(4-nitro-phenyl)-propionic acid 4-allyloxycarbonylmethoxy-benzyl ester 

Relevant academic research and scientific papers

Internal resin capture - A self purification method for the synthesis of C-terminally modified peptides

A synthetic strategy which allows for the general modification of peptides at the C-terminus has long been the goal of the synthetic chemist. We report here the full synthetic details of our inversion and modification methodology demonstrating the method with the synthesis of peptide amides, alcohols, nitriles and a range of other modified peptides.

2,3-DIPHENYLPROPIONIC ACID DERIVATIVES OR THEIR SALTS, MEDICINES OR CELL ADHESION INHIBITORS CONTAINING THE SAME, AND THEIR USAGE

A 2,3-diphenylpropionic acid derivatives or the salts represented by general formula (1) below; and pharmaceutical compositions and cell adhesion inhibitors comprising the derivatives or the salts as the active ingredient. In the formula, A, B and C indep

Optimising inhibitors of trypanothione reductase using solid-phase chemistry

A series of inhibitors of the enzyme trypanothione reductase has been identified using directed solid-phase chemistry. The compounds were based on a series of polyamine scaffolds and used the natural product kukoamine A as the lead structure. A compound with a K(i) of 76 nM was identified, although somewhat surprisingly the compound appeared to be noncompetitive in nature. (C) 2000 Elsevier Science Ltd.

Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support

Methods, compositions, and devices for synthesis of therapeutically useful compounds. The invention provides a rapid approach for combinatorial synthesis and screening of libraries of derivatives of therapeutically important classes of compounds such as benzodiazepines, prostaglandins and β-turn mimetics. In order to expediently synthesize a combinatorial library of derivatives based upon these core structures, general methodology for the solid phase synthesis of these derivatives is also provided. This disclosure thus also describes an important extension of solid phase synthesis methods to nonpolymeric organic compounds.