226250-40-4

Upstream product

• 2916-14-5 allyl chloroacetate 
• 123-08-0 4-hydroxy-benzaldehyde 
• 40630-84-0 allyl bromoacetate 

Downstream Products

• 155505-55-8 allyl (4-hydroxymethyl)phenoxyacetate 
• 313983-92-5 [4-({[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid allyl ester 
• 313983-90-3 [4-({bis-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid allyl ester 
• 313983-98-1 [4-({[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid 
• 313983-96-9 [4-({bis-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid 
• 213008-45-8 [4-({(4-{tert-Butoxycarbonyl-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-amino}-butyl)-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid allyl ester 
• 213008-46-9 [4-({(4-{tert-Butoxycarbonyl-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-amino}-butyl)-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid 
• 192064-31-6 4-nitrophenyl-4'-hydroxymethylphenyl-1'-oxyallylacetate carbonate 

Relevant academic research and scientific papers

Optimising inhibitors of trypanothione reductase using solid-phase chemistry

A series of inhibitors of the enzyme trypanothione reductase has been identified using directed solid-phase chemistry. The compounds were based on a series of polyamine scaffolds and used the natural product kukoamine A as the lead structure. A compound with a K(i) of 76 nM was identified, although somewhat surprisingly the compound appeared to be noncompetitive in nature. (C) 2000 Elsevier Science Ltd.

PHENYLAZETIDINONE DERIVATIVES

Various azetidinone derivatives are described, as are pharmaceutical compositions containing these compounds and methods of treatment of diseases using these compounds. Other embodiments are also described.

Internal resin capture - A self purification method for the synthesis of C-terminally modified peptides

A synthetic strategy which allows for the general modification of peptides at the C-terminus has long been the goal of the synthetic chemist. We report here the full synthetic details of our inversion and modification methodology demonstrating the method with the synthesis of peptide amides, alcohols, nitriles and a range of other modified peptides.