213008-46-9

Upstream product

• 71-44-3 Spermine 
• 155505-55-8 allyl (4-hydroxymethyl)phenoxyacetate 
• 226250-40-4 4-formylphenoxyallylacetate 
• 104435-59-8 1,12-diphthalimido-4,9-diazadodecane 
• 123-08-0 4-hydroxy-benzaldehyde 
• 22509-74-6 N-ethoxycarbonylphthalimide 
• 213008-45-8 [4-({(4-{tert-Butoxycarbonyl-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-amino}-butyl)-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid allyl ester 
• 192064-31-6 4-nitrophenyl-4'-hydroxymethylphenyl-1'-oxyallylacetate carbonate 

Downstream Products

• 75288-96-9 kukoamine A 

Relevant academic research and scientific papers

Optimising inhibitors of trypanothione reductase using solid-phase chemistry

A series of inhibitors of the enzyme trypanothione reductase has been identified using directed solid-phase chemistry. The compounds were based on a series of polyamine scaffolds and used the natural product kukoamine A as the lead structure. A compound with a K(i) of 76 nM was identified, although somewhat surprisingly the compound appeared to be noncompetitive in nature. (C) 2000 Elsevier Science Ltd.

The synthesis of symmetrical spermine conjugates using solid-phase chemistry

The utility of spermine, selectively functionalised and immobilised on a solid support by means of the Wang 'oxycarbonyl' linker is demonstrated by the solid-phase synthesis of a number of spermine conjugates including the natural product and potent antihypertensive agent kukoamine. The synthesis opens up the area of solid-phase spermine chemistry and library generation based on the symmetrical spermine scaffold.