15560-98-2Relevant articles and documents
Sulfone derivatives as 5-HT7 receptor ligands
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Page/Page column 6, (2010/02/09)
The present invention relates to sulfone derivatives of formula (I): Ar—SO2—CR2R3-L-N(R1)2??I wherein Ar, L, R1, R2 and R3 are as defined herein, and pharmaceutically
MONOALKYLATION AND MONOPHENYLATION OF ISOPROPYLTHIOPHENYL METHYL SELENIDES AND 2-PHENYLTHIOETHENYL METHYL SELENIDES WITH GRIGNARD REAGENTS PROMOTED BY LOW-VALENT NICKEL SPECIES. REGIO- AND STEREOSELECTIVE CLEAVAGE OF THE CARBON-SELENIUM BOND
Tingoli, Marco,Tiecco, Marcello,Testaferri, Lorenzo,Chianelli, Donatella
, p. 59 - 61 (2007/10/02)
The substitution of the methylselenium group in different (isopropylthio)phenyl and (phenylthio)ethenyl methyl selenides by alkyl and phenyl groups, through Grignard reaction mediated by phosphino-ligated nickel species, is described.In all cases this substitution occurs smoothly and at a rate which is fast enough to leave the C-S bond unaffected.In the olefinic series the use of a bidenate phosphine ligand on the nickel catalyst is required to promote the stereocontrolled cleavage of the C-Se bond in the case of the Z isomers.
SELECTIVE MONO-ARYLATION AND -ALKYLATION OF CHLOROPHENYL ALKYL SULFIDES BY NICKEL CATALYSED CROSS-COUPLING WITH GRIGNARD REAGENTS
Tiecco, Marcello,Testaferri, Lorenzo,Tingoli, Marco,Chianelli, Donatella,Wenkert, Ernest
, p. 4629 - 4632 (2007/10/02)
Chlorophenyl alkyl sulfides are mono-arylated and -alkylated selectively with Grignard reagents, in the presence of Ni(PPh3)2Cl2, to give aryl- and alkyl-phenyl alkyl sulfides.
