15560-98-2Relevant academic research and scientific papers
Sulfone derivatives as 5-HT7 receptor ligands
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Page/Page column 6, (2010/02/09)
The present invention relates to sulfone derivatives of formula (I): Ar—SO2—CR2R3-L-N(R1)2??I wherein Ar, L, R1, R2 and R3 are as defined herein, and pharmaceutically
Metallation Reactions. XVIII. Regioselective metallation of (alkylthio)benzenes by superbases
Cabiddu, S.,Fattuoni, C.,Floris, C.,Gelli, G.,Melis, S.
, p. 197 - 202 (2007/10/02)
(Alkylthio)benzenes were monometallated at the alpha position by a stoichiometric mixture of butyllithium and potassium t-butoxide and bimetallated at both the alpha and the ortho positions by two equivalents of the same reagent.
MONOALKYLATION AND MONOPHENYLATION OF ISOPROPYLTHIOPHENYL METHYL SELENIDES AND 2-PHENYLTHIOETHENYL METHYL SELENIDES WITH GRIGNARD REAGENTS PROMOTED BY LOW-VALENT NICKEL SPECIES. REGIO- AND STEREOSELECTIVE CLEAVAGE OF THE CARBON-SELENIUM BOND
Tingoli, Marco,Tiecco, Marcello,Testaferri, Lorenzo,Chianelli, Donatella
, p. 59 - 61 (2007/10/02)
The substitution of the methylselenium group in different (isopropylthio)phenyl and (phenylthio)ethenyl methyl selenides by alkyl and phenyl groups, through Grignard reaction mediated by phosphino-ligated nickel species, is described.In all cases this substitution occurs smoothly and at a rate which is fast enough to leave the C-S bond unaffected.In the olefinic series the use of a bidenate phosphine ligand on the nickel catalyst is required to promote the stereocontrolled cleavage of the C-Se bond in the case of the Z isomers.
SELECTIVE MONO-ARYLATION AND -ALKYLATION OF BIS(ALKYLTHIO)BENZENES; THE IMPORTANCE OF STERIC EFFECTS IN THE NICKEL-CATALYZED CROSS-COUPLING OF ARYL ALKYL SULPHIDES WITH GRIGNARD REAGENTS
Tiecco, M.,Testaferri, L.,Tingoli, M.,Wenkert, E.
, p. 2289 - 2294 (2007/10/02)
Synthetically useful procedures to effect selective conversion of C-S into C-C bonds have been developed by taking advantage of the sensitivity of reactions of Grignard reagents with aryl alkyl sulphides, catalyzed by low-valent nickel species, to steric effects.It is shown that the course of these reactions is influenced by the steric requirements of both the aryl and the alkyl moieties of the sulphides.Thus, selective mono-arylation and alkylation of easily available bis(alkylthio)benzenes can be effected in medium to high yields.This allows the introduction of two different aryl or alkyl groups into the benzene nucleus by sequential substitution of the two alkylthio functions.
SELECTIVE MONO-ARYLATION AND -ALKYLATION OF CHLOROPHENYL ALKYL SULFIDES BY NICKEL CATALYSED CROSS-COUPLING WITH GRIGNARD REAGENTS
Tiecco, Marcello,Testaferri, Lorenzo,Tingoli, Marco,Chianelli, Donatella,Wenkert, Ernest
, p. 4629 - 4632 (2007/10/02)
Chlorophenyl alkyl sulfides are mono-arylated and -alkylated selectively with Grignard reagents, in the presence of Ni(PPh3)2Cl2, to give aryl- and alkyl-phenyl alkyl sulfides.
