15566-30-0

Upstream product

• 100-44-7 benzyl chloride 
• 100-02-7 4-nitro-phenol 
• 1145-76-2 benzyl 4-nitrophenyl ether 
• 3598-13-8 (4-chlorophenoxy)acetonitrile 

Downstream Products

• 1007871-99-9 5-(benzyloxy)benzo[c]isoxazole-3-carboxamide 
• 155056-16-9 2-(2-nitro-5-benzyloxyphenyl)propionitrile 
• 161368-64-5 3-cyanomethyl p-aminophenol 
• 155056-14-7 2-(2-Amino-5-benzyloxy-phenyl)-propionitrile 
• 21987-24-6 5-(benzyloxy)-3-methyl-1H-indole 
• 1953-54-4 indol-5-ol 
• 130570-61-5 1-[(5'-benzyloxy-2'-nitro)phenyl]-2-cyanopropane 
• 152562-01-1 (Z)-2-(5-Benzyloxy-2-nitro-phenyl)-but-2-enenitrile 

Relevant academic research and scientific papers

An improved synthesis of 3-methyl-5-hydroxy protected indoles

The synthesis of 3-methyl-5-alkoxy indoles 14 and 15 was accomplished through the use of DIBALH to effect the reductive- cyclization of an amino-nitrile intermediate. The mild conditions used to induce cyclization allowed for the use of a benzyl protectin

Reactions of Organic Anions, 147.- Simple and General Synthesis of Hydroxy- and Methoxyindoles via Vicarious Nucleophilic Substitution of Hydrogen

A simple synthesis of 4-, 5-, 6-, and 7-hydroxy- and -methoxyindoles via cyanoalkylation of O-protected nitrophenols by vicarious nucleophilic substitution of hydrogen, followed by catalytic hydrogenation of the (2-nitroaryl)acetonitriles obtained is described.