155683-53-7

Basic information

• Product Name: 2-((4-bromo-2-fluorophenyl)methyl)-6-fluorospiro(isoquinoline-4(1H),3'-pyrrolidine)-1,2',3,5'(2H)-tetrone
• Synonyms: 2-((4-bromo-2-fluorophenyl)methyl)-6-fluorospiro(isoquinoline-4(1H),3'-pyrrolidine)-1,2',3,5'(2H)-tetrone
• CAS NO: 155683-53-7
• Molecular Formula: C19H11 Br F2 N2 O4
• Molecular Weight: 0
• Mol File: 155683-53-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 707.4°Cat760mmHg
• Flash Point: 381.6°C
• Appearance: /
• Density: 1.79g/cm³
• CAS DataBase Reference: 2-((4-bromo-2-fluorophenyl)methyl)-6-fluorospiro(isoquinoline-4(1H),3'-pyrrolidine)-1,2',3,5'(2H)-tetrone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((4-bromo-2-fluorophenyl)methyl)-6-fluorospiro(isoquinoline-4(1H),3'-pyrrolidine)-1,2',3,5'(2H)-tetrone(155683-53-7)
• EPA Substance Registry System: 2-((4-bromo-2-fluorophenyl)methyl)-6-fluorospiro(isoquinoline-4(1H),3'-pyrrolidine)-1,2',3,5'(2H)-tetrone(155683-53-7)

Safety Data

• Hazardous Substances Data: 155683-53-7(Hazardous Substances Data)

Upstream product

• 129689-16-3 (R)-2-(4-Bromo-2-fluoro-benzyl)-4-tert-butoxycarbonylmethyl-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 129689-18-5 (S)-2-(4-Bromo-2-fluoro-benzyl)-4-carboxymethyl-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 129688-68-2 2-[(4-Bromo-2-fluorophenyl)methyl]-6-fluoro-1,3(2H,3H)-isoquinolinedione 
• 1152315-50-8 6-fluorohomophthalic anhydride 
• 129689-22-1 (S)-2-(4-Bromo-2-fluoro-benzyl)-4-carbamoylmethyl-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 86119-84-8 phosphoric acid 
• 129688-97-7 4-(2-Amino-2-oxoethyl)-2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolinecarboxylic Acid Methyl Ester 

Relevant articles and documents

USE OF SUBSTITUTED 2 PHENYLBENZIMIDAZOLES AS MEDICAMENTS

The present invention relates to the use of a substituted 2-phenylbenzimidazole of formula I wherein R1, R2, R3, R 4, R5 and m have the meanings given in the claims, for the preparation of a medicament for the treatment or prevention of diseases involving glucagon receptors, as well as new compounds of formula I wherein R1 is a group of formula

PROCESS AND INTERMEDIATES FOR THE PREPARATION OF SPIRO(ISOQUINOLINE-4(1H), 3'-PYRROLIDINE)-1,2',3,5'(2H)-TETRONES WHICH ARE USEFUL AS ALDOSE REDUCTASE INHIBITORS

The invention relates to a process for producing spiroisoquinoline pyrrolidines. The compounds have pharmaceutical properties which render them beneficial for the prevention or treatment of diabetes mellitus associated complications.