155791-58-5

Upstream product

• 930-68-7 cyclohexenone 
• 67-56-1 methanol 
• 33948-36-6 2-iodocyclohex-2-en-1-one 
• 50870-61-6 2-bromocyclohex-2-en-1-one 
• 109380-07-6 2-bromocyclohex-2-en-1-ol 
• 155791-51-8 2-(Tri-n-butylstannyl)-2-cyclohexen-1-ol 

Downstream Products

• 222421-26-3 3-bromo-2-iodocyclohex-1-ene 
• 402593-90-2 ethyl 2-[(2-iodo-2-cyclohexenyl)oxy]acetate 
• 211696-89-8 3-(2-Iodo-cyclohex-2-enyloxymethyl)-cyclohexa-1,4-diene 
• 1189369-91-2 2-(pyridin-2-ylethynyl)cyclohex-2-enol 
• 1189369-90-1 2-(4-pentylphenylethynyl)cyclohex-2-enol 
• 1189369-93-4 2-(1-hydroxycyclohexylethynyl)cyclohex-2-enol 
• 93338-81-9 2-(phenylethynyl)cyclohex-2-en-1-ol 
• 1189369-92-3 2-hex-1-ynylcyclohex-2-enol 

Relevant academic research and scientific papers

β-Stannyl Allylic Alcohols through Photooxygenation (Schenck Reaction) of Vinylstannanes and Reduction of the Resulting Allylic Hydroperoxides: Synthesis and Selected Transformations

β-Stannyl allylic alcohols 2 were prepared regioselectively by photooxygenation (Schenck reaction) of the vinylstannanes 1 and subsequent reductionn of the resulting allylic hydroperoxides by sodium borohydride.This novel methodology makes the hitherto un

The dehydro Diels-Alder (DDA) reaction based approach to isofuranonaphthalenone, nodulones A-C and xestolactone A

An efficient and convenient synthesis of advanced (highly functionalized) tricyclic frame works present in the isofuranonaphthalenone, nodulones A-C and xestolactone A natural products has been achieved. The dehydro Diels-Alder reaction was employed as th

Synthesis of fused 1,2-naphthoquinones with cytotoxic activity using a one-pot three-step reaction

A method for the synthesis of fused 1,2-naphthoquinones, as analogues of biologically active natural terpene quinones, is described. The intermediate polycyclic naphthalenes were prepared by a one-pot palladium-catalysed process from simple alkynes, one o

Total Synthesis of (-)-Daphnezomines A and B

Daphnezomines A and B are structurally unusual Daphniphyllum alkaloids that contain a unique aza-adamantane core skeleton. Herein, a modular approach to these alkaloids is presented that exploits a diverse array of reaction strategies. Commencing from a chiral pool terpene-(S)-carvone, the azabicyclo[3.3.1]nonane backbone, which occurs widely in Daphniphyllum alkaloids, was easily accessed through a Sharpless allylic amination and a palladium-catalyzed oxidative cyclization. A protecting group enabled a stereoselective B-alkyl Suzuki-Miyaura coupling sequence and an Fe-mediated hydrogen atom transfer (HAT)-based radical cyclization were then applied to construct C6 and C8 stereocenters. A final epimer locking strategy enabled the assembly of the highly congested aza-adamantane core, thereby achieving the first total synthesis of (-)-daphnezomines A and B in 14 steps.

Enantioselective Copper Catalyzed Alkyne-Azide Cycloaddition by Dynamic Kinetic Resolution

The copper(I) catalyzed alkyne-azide cycloaddition (CuAAC), a click reaction, is one of the most powerful catalytic reactions developed during the last two decades. Conducting CuAAC enantioselectively would add a third dimension to this reaction and would

Palladium-Catalyzed Asymmetric Allylic Fluoroalkylation/Trifluoromethylation

The first palladium-catalyzed asymmetric allylic trifluoromethylation is disclosed. The methodology evokes a fundamental principle by which the synergistic interplay of a leaving group and its subsequent activation of the nucleophilic trifluoromethyl grou

Extrapolation of the gold-catalyzed cycloisomerization to the palladium-catalyzed cross-coupling/cycloisomerization of acetylenic alcohols for the synthesis of polysubstituted furans: Scope and application to tandem processes

This paper describes the development of an integrated approach for the preparation of diverse furan derivatives from acetylenic alcohols by gold and palladium catalyzed π-activation chemistry. Notably, this new method was found to be amenable to cycloocty

Palladium-catalyzed intramolecular reductive cross-coupling of Csp 2-Csp3 bond formation

A Pd-catalyzed efficient reductive cross-coupling reaction without metallic reductant to construct a Csp2-Csp3 bond has been reported. A PdIV complex was proposed to be a key intermediate, which subsequently went through d

Overcoming equilibrium issues with carbonyl reductase enzymes

We report herein the screening, optimisation and scale up to 100 g of a bioreduction process that employs an in situ product removal (ISPR) technique to overcome the inherent equilibrium problem associated with the coupled-substrate approach to biocatalyt

Unusual Au(III)-catalyzed dimerization of benzoxazol-2-yloxy enynes: Formation of substituted 1,5-cyclooctadienes

Symmetric 1,5-cyclooctadienes were formed via Au-catalyzed dimerization of benzoxazol-2-yloxy enynes, involving double nucleophilic attacks of alkenylgolds toward allylic cations.