155836-50-3 Usage
Biological Activity
ki: 1.8, 15, 85 and 34 nm for delta, mu, epsilon and kappa receptoropioid receptors are heterogeneous and at least four types, mu,.delta, kappa and epsilon, are known to exist. currently, all clinically used opiates act through the mu receptor to induce analgesia; however, they also induce unwanted side effects such as respiratory depression, dependence, constipation and muscle rigidity.bw 373u86 is a novel, potent and selective nonpeptidic delta opioid receptor agonist.
in vitro
bw 373u86 was a potent delta receptor-selective ligand in receptor binding assays. the ki values were 1 .8 ± 0.4, 15 ± 3, 85 ± 4 and 34 ± 3 nm for delta, mu, epsilon and kappa receptor binding sites, respectively. bw 373u86 inhibited electncally evoked muscle contraction of mouse vas deferens with an ed50 value of 0.2 ± 0.06 nm [1].
in vivo
bw 373u86 inhibited the acoustic startle reflex after subcutaneous administration from 0.2- to 2-mg/kg doses in rats, and this inhibition was blocked by naltnndole. bw 373u86 also induced a dose-dependent increase of locomotor activity in rats at similar doses. this effect was inhibited by naltnndole [3].
references
[1] chang kj, rigdon gc, howard jl, mcnutt rw. a novel, potent and selective nonpeptidic delta opioid receptor agonist bw 373u86. j pharmacol exp ther. 1993 nov;267(2):852-7.
Check Digit Verification of cas no
The CAS Registry Mumber 155836-50-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,5,8,3 and 6 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 155836-50:
(8*1)+(7*5)+(6*5)+(5*8)+(4*3)+(3*6)+(2*5)+(1*0)=153
153 % 10 = 3
So 155836-50-3 is a valid CAS Registry Number.
155836-50-3Relevant articles and documents
DELTA OPIOID AGONIST, MU OPIOID ANTAGONIST COMPOSITIONS AND METHODS FOR TREATING PARKINSON'S DISEASE
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, (2017/11/04)
The present invention provides for compositions and methods for the treatment of Parkinson's disease comprising a compound of formula (i): or a pharmaceutically effective salt or ester thereof alone or in combination with L-DOPA to provide a synergistic e
METHOD OF TREATING PARKINSON'S DISEASE WITH DIARYLMETHYLPIPERAZINE COMPOUNDS EXHIBITING DELTA RECEPTOR AGONIST ACTIVITY
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Page/Page column 16-17, (2010/11/26)
Compositions and methods for treatment of Parkinson's disease to reduce the negative side effects of the disease by administering a therapeutically effective diarylmethylpiperazine compound which exhibits delta opioid receptor agonist activity, and option
Probes for Narcotic Receptor Mediated Phenomena. 19. Synthesis of (+)-4--N,N-diethylbenzamide (SNC 80): A Highly Selective, Nonpeptide β Opioid Receptor Agonist
Calderon, Silvia N.,Rothman, Richard B.,Porreca, Frank,Flippen-Anderson, Judith L.,McNutt, Robert W.,et al.
, p. 2125 - 2128 (2007/10/02)
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