155846-39-2Relevant academic research and scientific papers
Novel polyene cyclisation routes to the acyl tetronic acid ionophore tetronasin (ICI M139603)
Boons, Geert-Jan,Lennon, Ian C.,Ley, Steven V.,Owen, Elaine S. E.,Staunton, James,Wadsworth, David J.
, p. 323 - 326 (1994)
An approach to the total synthesis of the ionophore antibiotic tetronasin (1) is reported, in which the key step is novel base catalysed cascade cyslisation of an activated polyene (2). This establishes two rings and four stereogenic centres in one step. A related polyene (16) has been cyclised in a similar fashion, illustrating the generality of the procedure.
Synthesis of the acyltetronic acid ionophore tetronasin (ICI M139603)
Ley, Steven V.,Brown, Dearg S.,Clase, J. Andrew,Fairbanks, Antony J.,Lennon, Ian C.,Osborn, Helen M. I.,Stokes, Elaine S. E.,Wadsworth, David J.
, p. 2259 - 2276 (2007/10/03)
A synthetic strategy for the preparation of tetronasin 1, an acyltetronic acid ionophore demonstrating antibiotic, antiparasitic and growth promotion in ruminants is described. The key step involves a metal mediated cyclization reaction which creates two
