86951-92-0Relevant academic research and scientific papers
Toward the synthesis of tulearin C: Stereoselective synthesis of the C1-C18 macrolactone core
Yadav,Venkatesh,Swapnil,Prasad
, p. 2336 - 2339 (2013/06/27)
The asymmetric and convergent synthesis of fully functionalized macrocyclic core of tulearin C is described. Sharpless asymmetric epoxidation, Gillman's reaction, olefin cross metathesis, α aminoxylation, and ring closing metathesis reactions are the key
Synthesis of the acyltetronic acid ionophore tetronasin (ICI M139603)
Ley, Steven V.,Brown, Dearg S.,Clase, J. Andrew,Fairbanks, Antony J.,Lennon, Ian C.,Osborn, Helen M. I.,Stokes, Elaine S. E.,Wadsworth, David J.
, p. 2259 - 2276 (2007/10/03)
A synthetic strategy for the preparation of tetronasin 1, an acyltetronic acid ionophore demonstrating antibiotic, antiparasitic and growth promotion in ruminants is described. The key step involves a metal mediated cyclization reaction which creates two
Novel polyene cyclisation routes to the acyl tetronic acid ionophore tetronasin (ICI M139603)
Boons, Geert-Jan,Lennon, Ian C.,Ley, Steven V.,Owen, Elaine S. E.,Staunton, James,Wadsworth, David J.
, p. 323 - 326 (2007/10/02)
An approach to the total synthesis of the ionophore antibiotic tetronasin (1) is reported, in which the key step is novel base catalysed cascade cyslisation of an activated polyene (2). This establishes two rings and four stereogenic centres in one step. A related polyene (16) has been cyclised in a similar fashion, illustrating the generality of the procedure.
Total Synthesis of (+)-Carbonolide B
Keck, Gary E.,Palani, Anandan,McHardy, Stanton F.
, p. 3113 - 3122 (2007/10/02)
The macrolide (+)-carbonolide B, the aglycon of the antibiotic carbomycin B, was synthesized via a convergent sequence.A key step of the approach is the union of aldehyde 6 with stannane 7 in the presence of MgBr2*OEt2 as Lewis acid to afford the C1-C9 fr
A NEW APPROACH TO 1,7-DIOXASPIROUNDEC-4-ENES VIA METALLATED ALLENOL ETHERS. SYNTHESIS OF LACRIMIN A.
Takle, Andrew,Kocienski, Philip
, p. 4503 - 4516 (2007/10/02)
Key steps in the first total synthesis of Lacrimin A (2) include (a) the use of methoxyallene as an enone-1,3-dianion equivalent; (b) the use of a new copper-catalysed migratory insertion reaction to construct a tri-substituted alkene stereoselectively; and (c) the use of a Pd(0)-catalysed coupling reaction to generate an isochromanone ring.
