Novel polyene cyclisation routes to the acyl tetronic acid ionophore tetronasin (ICI M139603)

DOI: 10.1016/S0040-4039(00)76543-9

Source and publish data:

Tetrahedron Letters p. 323 - 326 (1994)

Update date:2022-07-29

Topics:

Authors:

Boons, Geert-Jan

Lennon, Ian C.

Ley, Steven V.

Owen, Elaine S. E.

Staunton, James

Wadsworth, David J.

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Article abstract of DOI:10.1016/S0040-4039(00)76543-9

An approach to the total synthesis of the ionophore antibiotic tetronasin (1) is reported, in which the key step is novel base catalysed cascade cyslisation of an activated polyene (2). This establishes two rings and four stereogenic centres in one step. A related polyene (16) has been cyclised in a similar fashion, illustrating the generality of the procedure.

Full text of DOI:10.1016/S0040-4039(00)76543-9

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