155852-41-8

Usage

Uses

Used in Organic Synthesis:
2,3-Dihydro-5-benzofuranacetic acid methyl ester is used as a synthetic intermediate for the creation of various complex organic molecules. Its unique structure allows it to serve as a building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,3-Dihydro-5-benzofuranacetic acid methyl ester is used as a key component in the development of new drugs. Its chemical properties make it suitable for the synthesis of novel therapeutic agents, potentially leading to the discovery of innovative treatments for various diseases and medical conditions.
Used in Agrochemical Industry:
2,3-Dihydro-5-benzofuranacetic acid methyl ester also finds application in the agrochemical industry, where it is utilized in the synthesis of new pesticides, herbicides, and other crop protection agents. Its incorporation into these products can contribute to the development of more effective and environmentally friendly solutions for agricultural challenges.
Used in Specialty Chemicals:
2,3-Dihydro-5-benzofuranacetic acid methyl ester is also used in the production of specialty chemicals, which are tailored to meet the specific requirements of various industries. The versatility of 2,3-Dihydro-5-benzofuranacetic acid methyl ester makes it a valuable asset in the development of customized chemical products for applications such as coatings, adhesives, and polymers.

InChI:InChI=1/C11H12O3/c1-13-11(12)7-8-2-3-10-9(6-8)4-5-14-10/h2-3,6H,4-5,7H2,1H3

Upstream product

• 156-38-7 4-hydroxyphenylacetate 
• 121638-36-6 methyl 2-(benzofuran-5-yl)acetate 
• 67-56-1 methanol 
• 69999-16-2 2,3-dihydrobenzofuran-5-acetic acid 

Downstream Products

• 69999-16-2 2,3-dihydrobenzofuran-5-acetic acid 
• 127264-14-6 2,3-dihydro-5-(2-bromoethyl)benzofuran 
• 87776-76-9 5-(2-hydroxyethyl)-2,3-dihydrobenzofuran 

Relevant academic research and scientific papers

Iridium-Catalyzed Amidation of in Situ Prepared Silyl Ketene Acetals to Access α-Amino Esters

Disclosed herein is a convenient Ir-catalyzed amidation of esters to access α-amido esters. Initially prepared silyl ketene acetals are directly employed, without separate purification, for subsequent amidation with an oxycarbonylnitrenoid precursor using the Cp*(LX)Ir(III) catalyst. The α-amidation was facile for both α-aryl and α-alkyl esters. Density functional theory studies revealed that the generation of a putative Ir-nitrenoid is facilitated by the chelation of the countercation additive during the N-O bond cleavage of the nitrene precursor.

Palladium/TY-Phos-Catalyzed Asymmetric Intermolecular α-Arylation of Aldehydes with Aryl Bromides

Despite much progress has been made in the asymmetric α-arylation reactions of cyclic ketones, lactones and lactams, the enantioselective α-arylation of acyclic carbonyl compounds lagged much behind due to the in situ generated Z/E-enolate intermediates l

Darifenacin intermediate 2, 3 - dihydro - 5 - benzofuran acetic acid preparation new method of (by machine translation)

The invention relates to a darifenacin intermediate - 2, 3 - dihydro - 5 - benzofuran acetic acid. By the P-hydroxy-acetic acid and bromo acetaldehyde acetal as the starting material, the presence of O - alkylation reaction under a condition of the corresponding ether compound; then by esterification reaction to obtain the corresponding ester; in PPA (poly phosphoric acid) under the action of the, cyclization to obtain 2, 3 - benzofuran - 5 - acetate; 2, 3 - benzofuran - 5 - acetic acid layer which hydrolysis, to acidify the corresponding carboxylic acid; obtained by catalytic hydrogenation of 2, 3 - dihydro - 5 - benzofuran acetic acid; or the first 2, 3 - benzofuran - 5 - acetate obtained by catalytic hydrogenation of 2, 3 - dihydro - 5 - benzofuran acetic acid esters; and hydrolyzed, acidified to obtain 2, 3 - dihydro - 5 - benzofuran acetic acid. The method of the invention by simple and safe, each reaction raw materials are cheap and easy to obtain, the reaction yield is high, and is particularly suitable for industrial production of 2, 3 - dihydro - 5 - benzofuran acetic acid. (by machine translation)

COMPOUNDS AND COMPOSITIONS AND USES THEREOF

Disclosed are compounds of formula (I): and pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disease and disorders in a subject in need are also disclosed.

Benzoheterocycle derivative having [beta]2 agonist activity, preparation method, and application thereof

The invention relates to a benzoheterocycle derivative having [beta]2 agonist activity, a preparation method, and an application thereof, and in particularly, relates to a compound represented as the general formula (I), or a stereoisomer, a hydrate, a me

PROCESSES FOR PREPARING DARIFENACIN HYDROBROMIDE

The invention encompasses processes for the preparation of darifenacin hydrobromide.