155852-41-8Relevant articles and documents
Iridium-Catalyzed Amidation of in Situ Prepared Silyl Ketene Acetals to Access α-Amino Esters
Chang, Sukbok,Gwon, Yunyeong,Kim, Dongwook,Lee, Minhan
supporting information, p. 1088 - 1093 (2022/02/10)
Disclosed herein is a convenient Ir-catalyzed amidation of esters to access α-amido esters. Initially prepared silyl ketene acetals are directly employed, without separate purification, for subsequent amidation with an oxycarbonylnitrenoid precursor using the Cp*(LX)Ir(III) catalyst. The α-amidation was facile for both α-aryl and α-alkyl esters. Density functional theory studies revealed that the generation of a putative Ir-nitrenoid is facilitated by the chelation of the countercation additive during the N-O bond cleavage of the nitrene precursor.
COMPOUNDS AND COMPOSITIONS AND USES THEREOF
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Paragraph 0361; 0362, (2018/02/28)
Disclosed are compounds of formula (I): and pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disease and disorders in a subject in need are also disclosed.
Benzoheterocycle derivative having [beta]2 agonist activity, preparation method, and application thereof
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Paragraph 0105; 0107-0111, (2017/08/23)
The invention relates to a benzoheterocycle derivative having [beta]2 agonist activity, a preparation method, and an application thereof, and in particularly, relates to a compound represented as the general formula (I), or a stereoisomer, a hydrate, a me