2,3-Dihydro-5-benzofuranacetic acid methyl ester

Base Information

• Chemical Name: 2,3-Dihydro-5-benzofuranacetic acid methyl ester
• CAS No.: 155852-41-8
• Molecular Formula: C11H12O3
• Molecular Weight: 192.214
• Hs Code.: 2932999099
• Mol file: 155852-41-8.mol

Synonyms:2,3-Dihydro-5-benzofuranacetic Acid Methyl Ester;Methyl 2-(2,3-dihydrobenzofuran-5-yl)acetate;2-(2,3-Dihydrobenzofuran-5-yl)acetic Acid Methyl Ester

Chemical Property of 2,3-Dihydro-5-benzofuranacetic acid methyl ester

Chemical Property:

• Vapor Pressure: 0.00243mmHg at 25°C
• Boiling Point: 287.8°C at 760 mmHg
• Flash Point: 116.1°C
• PSA: 35.53000
• Density: 1.183g/cm³
• LogP: 1.33700
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Chloroform (Slightly), Dichloromethane, Ethyl Acetate, Methanol (Slightly)

Purity/Quality:

99.9% ^*data from raw suppliers

2,3-Dihydro-5-benzofuranaceticAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,3-Dihydro-5-benzofuranacetic Acid Methyl Ester (cas# 155852-41-8) is a compound useful in organic synthesis.

Technology Process of 2,3-Dihydro-5-benzofuranacetic acid methyl ester

There total 5 articles about 2,3-Dihydro-5-benzofuranacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methanol (67-56-1) + 2,3-dihydrobenzofuran-5-acetic acid (69999-16-2) → methyl 2-(2,3-dihydrobenzofuran-5-yl)acetate (155852-41-8)

Guidance literature:

With thionyl chloride; at 80 ℃; for 0.333333h;

Reference yield: 90.6%

methyl 2-(benzofuran-5-yl)acetate (121638-36-6) → methyl 2-(2,3-dihydrobenzofuran-5-yl)acetate (155852-41-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; at 65 - 70 ℃; under 3040.2 - 3800.26 Torr;

Reference yield:

4-hydroxyphenylacetate (156-38-7) → methyl 2-(2,3-dihydrobenzofuran-5-yl)acetate (155852-41-8)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium iodide; sodium hydroxide / dimethyl sulfoxide / 50 - 80 °C

2: toluene-4-sulfonic acid / Reflux; Large scale

3: polyphosphoric acid / toluene / 105 - 110 °C

4: hydrogen; acetic acid; palladium 10% on activated carbon / methanol / 65 - 70 °C / 3040.2 - 3800.26 Torr

With palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; acetic acid; potassium iodide; sodium hydroxide; In methanol; dimethyl sulfoxide; toluene;

upstream raw materials:

methanol

2,3-dihydrobenzofuran-5-acetic acid

4-hydroxyphenylacetate

methyl 2-(benzofuran-5-yl)acetate

Downstream raw materials:

2,3-dihydrobenzofuran-5-acetic acid

2,3-dihydro-5-(2-bromoethyl)benzofuran

5-(2-hydroxyethyl)-2,3-dihydrobenzofuran

Refernces

• 1、 Li, Wenbo,Liu, Feng,Pan, Zhangjin,Wu, Hai-Hong,Zhang, Junliang,Zhu, Shuai. "Palladium/TY-Phos-Catalyzed Asymmetric Intermolecular α-Arylation of Aldehydes with Aryl Bromides". supporting information. p. 18542 - 18546. Retrieved 2021/07/21.
• 2、 -. "Darifenacin intermediate 2, 3 - dihydro - 5 - benzofuran acetic acid preparation new method of (by machine translation)". . . Retrieved 2018/04/03.