156026-91-4

Upstream product

• 98-88-4 benzoyl chloride 
• 156026-83-4 (E)-3-[3-(Hydroxy-phenyl-methyl)-pyrrol-1-yl]-acrylic acid ethyl ester 
• 156026-79-8 (E)-3-(3-Benzoyl-pyrrol-1-yl)-acrylic acid ethyl ester 
• 81453-99-8 1-(phenylsulfonyl)-3-benzoylpyrrole 
• 7126-41-2 3-benzoylpyrrole 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 156026-87-8 (E)-3-[3-(Imidazol-1-yl-phenyl-methyl)-pyrrol-1-yl]-acrylic acid ethyl ester 

Downstream Products

• 156026-95-8 3-(Imidazol-1-yl-phenyl-methyl)-1'H-[1,3']bipyrrolyl-4'-carboxylic acid 

Relevant academic research and scientific papers

Antifungal agents. VIII. Synthesis and antifungal activities of bipyrryl analogues of bifonazole

Various bipyrryl analogues of bifonazole were synthesized starting from aryl-3-pyrryl-1-imidazolylmethanes. The introduction of a second pyrryl portion was performed by linking an acrylate moiety at 1-position of the pyrrole ring and then by treatment with TosMIC. The bipyrryl esters were hydrolyzed and decarboxylated to afford the required imidazoles. All new imidazole derivatives were tested against Candida albicans and Candida spp using as standard controls miconazole, bifonazole and ketoconazole.