81453-99-8

Basic information

• Product Name: 1H-Pyrrole, 3-benzoyl-1-(phenylsulfonyl)-
• CAS NO: 81453-99-8
• Molecular Formula: C17H13NO3S
• Molecular Weight: 311.361
• Mol File: 81453-99-8.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole, 3-benzoyl-1-(phenylsulfonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole, 3-benzoyl-1-(phenylsulfonyl)-(81453-99-8)
• EPA Substance Registry System: 1H-Pyrrole, 3-benzoyl-1-(phenylsulfonyl)-(81453-99-8)

Safety Data

• Hazardous Substances Data: 81453-99-8(Hazardous Substances Data)

Upstream product

• 16851-82-4 N-phenylsulfonylpyrrole 
• 98-88-4 benzoyl chloride 
• 2227-79-4 benzenecarbothioamide 
• 98-09-9 benzenesulfonyl chloride 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 156026-74-3 1-[(1-Benzenesulfonyl-1H-pyrrol-3-yl)-phenyl-methyl]-1H-imidazole 
• 1384865-53-5 C₂₁H₁₈N₂O₂S 
• 33234-57-0 3-benzyl-1H-pyrrole 
• 147089-53-0 2,4-bis(2-phenyl-1,3-benzodithiol-2-yl)pyrrole 
• 147089-32-5 4-(2-phenyl-1,3-benzodithiol-2-yl)-2-(2-phenyl-1,3-benzoxathiol-2-yl)pyrrole 
• 147089-52-9 4-(2-phenyl-1,3-benzodithiol-2-yl)-2-(4-toluoyl)pyrrole 
• 147089-06-3 4-benzoyl-2-(2-phenyl-1,3-benzodithiol-2-yl)pyrrole 
• 147089-42-7 2-benzoyl-4-(2-phenyl-1,3-benzodithiol-2-yl)pyrrole 
• 147089-24-5 3-(2-phenyl-1,3-benzodithiol-2-yl)pyrrole 
• 147088-89-9 2,4-dibenzoylpyrrole 
• 147088-97-9 1-(4-Benzoyl-1H-pyrrol-2-yl)-hexan-1-one 
• 156026-91-4 3-(Imidazol-1-yl-phenyl-methyl)-1'H-[1,3']bipyrrolyl-4'-carboxylic acid ethyl ester 
• 156026-95-8 3-(Imidazol-1-yl-phenyl-methyl)-1'H-[1,3']bipyrrolyl-4'-carboxylic acid 
• 156026-87-8 (E)-3-[3-(Imidazol-1-yl-phenyl-methyl)-pyrrol-1-yl]-acrylic acid ethyl ester 

Relevant articles and documents

Ketorolac impurity C and preparation method and application thereof

The invention discloses a ketorolac impurity C and a preparation method and application thereof. According to the method, the ketorolac impurity C is prepared by taking pyrrole as an initial raw material through a series of reactions such as substitution,

Antimalarial activity of natural and synthetic prodiginines

Prodiginines are a family of linear and cyclic oligopyrrole red-pigmented compounds. Herein we describe the in vitro antimalarial activity of four natural (IC50 = 1.7-8.0 nM) and three sets of synthetic prodiginines against Plasmodium falciparum. Set 1 compounds replaced the terminal nonalkylated pyrrole ring of natural prodiginines and had diminished activity (IC 50 > 2920 nM). Set 2 and set 3 prodiginines were monosubstituted or disubstituted at either the 3 or 5 position of the right-hand terminal pyrrole, respectively. Potent in vitro activity (IC50 = 0.9-16.0 nM) was observed using alkyl or aryl substituents. Metacycloprodiginine and more potent synthetic analogues were evaluated in a P. yoelii murine patent infection using oral administration. Each analogue reduced parasitemia by more than 90% after 25 (mg/kg)/day dosing and in some cases provided a cure. The most favorable profile was 92% parasite reduction at 5 (mg/kg)/day, and 100% reduction at 25 (mg/kg)/day without any evident weight loses or clinical overt toxicity.

The regioselective photoinduced aroylation at the 3-position of pyrrole derivatives

Irradiation of arenecarbothioamide with pyrrole or indole derivatives gave regioselectively 3-aroylpyrrole or -indole derivatives, respectively.