156337-32-5

Usage

Uses

Used in Pharmaceutical Industry:
5-(4-CHLOROPHENYL)-4-METHYL-3-(1-(2-PHENYLETHYL)PIPERIDIN-4-YL)ISOXAZOLE HYDROCHLORIDE is used as a D4 dopamine receptor antagonist for the treatment of psychological diseases such as depression and schizophrenia. Its antagonistic activity at the D4 receptor is believed to contribute to its antipsychotic effects, making it a valuable compound in the development of novel therapeutics for these conditions.
Additionally, due to its specific receptor targeting, it may also be used in research settings to study the role of the D4 dopamine receptor in various physiological and pathological processes, further expanding its applications in the pharmaceutical and biotechnology industries.

Biological Activity

A potent and highly selective D 4 dopamine receptor antagonist, with K i values of > 1700, 770 and 3.5 nM at cloned human D 2 , D 3 and D 4 receptors.

InChI:InChI=1/C23H25ClN2O/c1-17-22(25-27-23(17)20-7-9-21(24)10-8-20)19-12-15-26(16-13-19)14-11-18-5-3-2-4-6-18/h2-10,19H,11-16H2,1H3

Upstream product

• 6285-05-8 4'-chloropropiophenone 
• 176915-47-2 4-[3-(4-Chloro-phenyl)-2-methyl-3-oxo-propionyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 1027893-57-7 1-(4-Chloro-phenyl)-2-methyl-3-piperidin-4-yl-propane-1,3-dione 
• 103-63-9 1-phenyl-2-bromoethane 
• 498-94-2 isonipecotic acid 
• 293744-38-4 tert-butyl 4-(1H-imindazole-1-carbonyl)piperidine-1-carboxylate 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 1025948-15-5 (Z)-3-(4-Chloro-phenyl)-3-hydroxy-2-methyl-1-(1-phenethyl-piperidin-4-yl)-propenone 
• 184374-63-8 4-[3-(4-chlorophenyl)-2-methyl-1,3-dioxoprop-1-yl]-1-(2-phenylethyl)piperidine 

Relevant academic research and scientific papers

4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor

5-(4-Chlorophenyl)-3-(1-(4-chlorobenzyl)piperidin-4-yl)pyrazole (3) was identified from screening of the Merck sample collection as a human dopamine D4 (hD4) receptor ligand with moderate affinity (61 nM) and 4-fold selectivity over human D2 (hD2) recepto

DOPAMINE RECEPTOR SUBTYPE LIGANDS

Compounds of formula (I) STR1 wherein one of X and Y represents nitrogen, and the other of X and Y represents oxygen, sulphur or N--R 2 ; Q represents a substituted five-or six-membered monocyclic heteroaliphatic ring which contains one nitrogen atom as t

Alpha1a adrenergic receptor antagonists

Compounds that specifically bind to the human alpha1a adrenergic receptor, including compounds effective to reduce symptoms of benign prostatic hypertrophy include compounds of formula: STR1 wherein: Ar1 and Ar2 can be independantly aromatic, heteroaromatic, or condensed heteroaromatic unsubstituted or substituted with amino, alkoxy, sulfonamido, alkyl, heteroalkyl, halo;m is 0 or 1;n is 0, 1, or 2;het is an aromatic or nonaromatic heterocyclic ring, substituted with alkyl, halo, or alkoxy substituents; andX is a branched or straight chain aliphatic or halogen substituent.