1567351-20-5

Basic information

• Product Name: N-(2-butoxy-8-methyl-7-((1-methylpiperidin-4-yl)oxy)quinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide
• Synonyms: N-(2-butoxy-8-methyl-7-((1-methylpiperidin-4-yl)oxy)quinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide
• CAS NO: 1567351-20-5
• Molecular Weight: 583.728
• Mol File: 1567351-20-5.mol

Chemical Properties

• CAS DataBase Reference: N-(2-butoxy-8-methyl-7-((1-methylpiperidin-4-yl)oxy)quinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-butoxy-8-methyl-7-((1-methylpiperidin-4-yl)oxy)quinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide(1567351-20-5)
• EPA Substance Registry System: N-(2-butoxy-8-methyl-7-((1-methylpiperidin-4-yl)oxy)quinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide(1567351-20-5)

Safety Data

• Hazardous Substances Data: 1567351-20-5(Hazardous Substances Data)

Upstream product

• 5460-31-1 3-nitro-o-cresol 
• 4837-88-1 6-methoxy-2-nitrotoluene 
• 19500-02-8 2-methyl-3-methoxyaniline 
• 1567348-62-2 N-(3-methoxy-2-methylphenyl)cinnamamide 
• 1567350-29-1 N-(7-(benzyloxy)-2-butoxy-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide 
• 1567349-36-3 7-(benzyloxy)-2-butoxy-8-methylquinolin-3-amine 
• 1567349-09-0 7-(benzyloxy)-3-bromo-2-butoxy-8-methylquinoline 
• 106-52-5 N-methyl-4-hydroxypiperidine 
• 1567350-51-9 N-(2-butoxy-7-hydroxy-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide 
• 1567348-88-2 7-(benzyloxy)-2-butoxy-8-methylquinoline 
• 1567348-80-4 7-(benzyloxy)-8-methylquinolin-2(1H)-one 
• 154521-00-3 7-hydroxy-8-methylquinolin-2(1H)-one 

Relevant articles and documents

Synthesis and biological evaluation of coumarin replacements of novobiocin as Hsp90 inhibitors

Since Hsp90 modulates all six hallmarks of cancer simultaneously, it has become an attractive target for the development of cancer chemotherapeutics. In an effort to develop more efficacious compounds for Hsp90 inhibition, novobiocin analogues were prepared by replacing the central coumarin core with naphthalene, quinolinone, and quinoline surrogates. These modifications allowed for modification of the 2-position, which was previously unexplored. Biological evaluation of these compounds suggests a hydrophobic pocket about the 2-position of novobiocin. Anti-proliferative activities of these analogues against multiple cancer cell lines identified 2-alkoxyquinoline derivatives to exhibit improved activity.