1567372-00-2

Upstream product

• 1586755-75-0 C₂₃H₂₅Cl₂N₃O₃ 
• 4530-20-5 BOC-glycine 
• 158979-29-4 2-((tert-butoxycarbonyl)(prop-2-yn-1-yl)-amino)acetic acid 
• 1567373-38-9 2-((t-butoxycarbonyl)(3-(4-chlorophenyl)prop-2-yn-1-yl)amino)acetic acid 
• 1613081-98-3 C₂₃H₂₆ClN₃O₄ 
• 1567373-46-9 t-butyl 3-bromo-2-(2-methoxyphenyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate 
• 1679-18-1 4-Chlorophenylboronic acid 
• 1586755-65-8 t-butyl (3-bromoprop-2-yn-1-yl)(2-chloro-2-(2-(2-methoxyphenyl)hydrazono)ethyl)carbamate 
• 1567373-44-7 t-butyl (3-bromoprop-2-yn-1-yl)(2-(2-(2-methoxyphenyl)hydrazinyl)-2-oxoethyl)carbamate 
• 1567373-43-6 2-((3-bromoprop-2-yn-1-yl)(t-butoxycarbonyl)amino)acetic acid 

Downstream Products

• 1607795-05-0 C₂₀H₂₀ClN₃O 
• 1567372-19-3 3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-[(1-methylethyl)sulfonyl]-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 
• 1567372-48-8 3-(4-chlorophenyl)-5-(cyclohexylsulfonyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 
• 1567372-24-0 3-(4-chlorophenyl)-2-(2-methoxyphenyl)-N,N-dimethyl-2,6-dihydropyrrolo[3,4-c]pyrazole-5(4H)-sulfonamide 
• 1567372-98-8 3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(morpholin-4-ylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 
• 1567373-01-6 3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(piperidin-1-ylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 
• 1567372-73-9 N-(2-{[3-(4-chlorophenyl)-2-(2methoxyphenyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]sulfonyl}ethyl)methanesulfonamide 
• 1567372-53-5 5-(benzylsulfonyl)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 
• 1567372-11-5 3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 

Relevant academic research and scientific papers

Discovery and SAR of novel tetrahydropyrrolo[3,4-c]pyrazoles as inhibitors of the N-type calcium channel

A novel series of substituted tetrahydropyrrolo[3,4-c]pyrazoles were investigated as blockers of the N-type calcium channel (Cav2.2 channels), a chronic pain target.

Synthesis of substituted 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles and 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles by intramolecular nitrilimine cycloaddition

Both substituted 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles and 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles have been synthesized by the 3+2 intramolecular dipolar cycloaddition of nitrilimines to alkynes. This cyclization has been extended to more versatile 3-bromo derivatives by the use of alkynylbromides as dipolarophiles.

PYRROLOPYRAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: Formula. (I) wherein R1, R2 R3, Q, and G are defined herein.