1568-11-2

Basic information

• Product Name: CINNAMALAZINE
• Synonyms: CINNAMALDEHYDE AZINE;CINNAMALAZINE;LABOTEST-BB LT02096507;cinnamaldazine
• CAS NO: 1568-11-2
• Molecular Formula: C18H16N2
• Molecular Weight: 260.33
• EINECS: 216-371-9
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 1568-11-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 176 °C
• Boiling Point: 419.3°Cat760mmHg
• Flash Point: 200°C
• Appearance: /
• Density: 0.94g/cm³
• Vapor Pressure: 7.46E-07mmHg at 25°C
• Refractive Index: 1.542
• PKA: 6.96±0.50(Predicted)
• CAS DataBase Reference: CINNAMALAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: CINNAMALAZINE(1568-11-2)
• EPA Substance Registry System: CINNAMALAZINE(1568-11-2)

Safety Data

• Hazardous Substances Data: 1568-11-2(Hazardous Substances Data)

Usage

General Description

Cinnamalazine is a chemical compound with the molecular formula C14H10N2O2. It is a yellow powder that is insoluble in water but soluble in organic solvents such as ethanol and acetone. Cinnamalazine is a derivative of cinnamaldehyde, which is the organic compound that gives cinnamon its characteristic flavor and aroma. It has been studied for its potential biological and pharmacological properties, including its antioxidant and anti-inflammatory effects. Research on cinnamalazine is ongoing, and it has shown promise as a potential therapeutic agent for a variety of health conditions. However, further research is needed to fully understand its mechanisms of action and potential applications.

InChI:InChI=1/C18H16N2/c1-3-9-17(10-4-1)13-7-15-19-20-16-8-14-18-11-5-2-6-12-18/h1-16H

Upstream product

• 104-55-2 3-phenyl-propenal 
• 93922-77-1 6-methyl-4-oxo-9-(3-phenyl-allylidene)-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester 
• 14371-10-9 (E)-3-phenylpropenal 
• 76139-42-9 N-thioacetylaminoacetamidrazone 
• 64-17-5 ethanol 

Downstream Products

• 113854-46-9 1-(4-nitrophenyl)-3-ethoxycarbonyl-4-cinnamylideneamino-5-styryl-1,2,4-Δ²-triazoline 
• 104727-60-8 phenyl-12(phenyl-2-ethenyl)-3-diaza-1,2-cyclotetradecatetraene-1,5,9,13 
• 51627-04-4 di(phenyl-2-etenyl)-3,12-diaza-1,2-cyclododecatriene-1,5,9 
• 104-55-2 3-phenyl-propenal 
• 302-01-2 hydrazine 
• 479071-43-7 [(CO)3Fe(η4-N,N'-bis-(3-phenyl-allylidene)-hydrazine)] 
• 478957-25-4 [(CO)3Fe(N,N'-bis-(3-phenyl-allylidene)-hydrazine)Fe(CO)3] 
• 909863-25-8 1,5-distyryl-2H,6H-perhydrotriazolo-[1,2-a]triazole-3,7-dithione 
• 1216-15-5 cinnamaldehyde phenylhydrazone 
• 3839-82-5 cinnamaldehyde semicarbazone 

Relevant articles and documents

Glucose:urea:NH4Cl low melting mixture for the synthesis of symmetric azines

Alternate reaction media have become very important due to the problems created by the highly volatile nature of the solvents. The deep eutectic mixture is a kind of an alternate reaction medium which has emerged in recent years. Low melting mixtures were introduced by making the deep eutectic mixture more cost-effective and renewable by introducing carbohydrates into it. The properties of low melting mixtures include easiness to prepare, usage of low-cost components, biodegradability, solubility in water, easy separation from organic compounds, etc. The low melting mixtures such as glucose:urea:NH4Cl, glucose:ChCl, glucose:urea:ChCl, glycerol:urea:NH4Cl, and ethylene glycol:urea:NH4Cl were used in different ratios for the reactions. The properties such as viscosity, density, acidity, glass transition temperature, and thermal stability were studied. An unusual method for the synthesis of symmetrical azines is introduced wherein benzaldehyde and hydroxylamine are reacted in the presence of glucose:urea:NH4Cl. The method of synthesis needs only less reaction time, temperature and the product was easily separated. The products were confirmed using GC-MS and NMR techniques. The recyclability of glucose:urea:NH4Cl was studied.

Rapid, chemoselective and facile synthesis of azines by hydrazine/I2

We report the reaction of hydrazine hydrate with carbonyl compounds in the presence of molecular iodine at 0-10°C, which affords symmetrical azines in excellent yields in 1 to 4 min without any adverse effect on other substituents. The reactions are rapid and chemoselective, afford excellent yields, and have high-purity products. The workup procedure is environmentally benign and does not require solvent extraction. Copyright Taylor & Francis Group, LLC.

A convenient synthesis of azines under solvent-free conditions using microwave irradiation

In an extremely fast method the reaction of hydrazine sulfate with a number of aldehydes and ketones, is accelerated by microwave irradiation under solvent free conditions in the presence of CH2CO2Na/CaCl2 to afford high yields of relevant azines.