1216-15-5

Basic information

• Product Name: (2E)-1-phenyl-2-(3-phenylprop-2-en-1-ylidene)hydrazine
• CAS NO: 1216-15-5
• Molecular Formula: C₁₅H₁₄N₂
• Molecular Weight: 222.2851
• Mol File: 1216-15-5.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 380.382°C at 760 mmHg
• Flash Point: 183.848°C
• Density: 0.981g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: (2E)-1-phenyl-2-(3-phenylprop-2-en-1-ylidene)hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-1-phenyl-2-(3-phenylprop-2-en-1-ylidene)hydrazine(1216-15-5)
• EPA Substance Registry System: (2E)-1-phenyl-2-(3-phenylprop-2-en-1-ylidene)hydrazine(1216-15-5)

Safety Data

• Hazardous Substances Data: 1216-15-5(Hazardous Substances Data)

Usage

General Description

The chemical (2E)-1-phenyl-2-(3-phenylprop-2-en-1-ylidene)hydrazine, also known as chalcone hydrazone, is an organic compound with a hydrazone functional group. It is a derivative of chalcone, a natural compound found in various plants. Chalcone hydrazone has been investigated for its potential biological activities, including anti-inflammatory, anti-cancer, and antibacterial properties. It has also been studied as a potential ligand in coordination chemistry. The compound's structure consists of a phenyl group connected to a hydrazone moiety, and it is commonly used as a building block in organic synthesis. Additionally, chalcone hydrazone has shown promise in the development of new materials, such as dyes and polymers, due to its ability to undergo various chemical reactions. (Note: The chemical name provided has been interpreted as "(2E)-1-phenyl-2-(3-phenylprop-2-en-1-ylidene)hydrazine" but may be subject to interpretation or correction by a chemistry expert.)

Upstream product

• 59-88-1 phenylhydrazine hydrochloride 
• 104-55-2 3-phenyl-propenal 
• 100-63-0 phenylhydrazine 
• 74327-75-6 EE-3-phenyl-1-phenylazo-1-propene 
• 37973-54-9 1,1-diacetoxy-3-phenylprop-2-ene 
• 14371-10-9 (E)-3-phenylpropenal 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 13372-81-1 cinnamaldoxime 
• 7647-01-0 hydrogenchloride 
• 7732-18-5 water 
• 127-09-3 sodium acetate 
• 64-17-5 ethanol 
• 56139-41-4 1-phenylazo-2-piperidinoethene 
• 1589-82-8 phenylmagnesium bromide 

Downstream Products

• 115188-95-9 2-(N'''-phenyl-3-trans-styryl-formazano)-benzoic acid 
• 100968-90-9 N-phenyl-trans-cinnamamidine 
• 25286-31-1 acetic acid-(cinnamylidene-phenyl-hydrazide) 
• 2515-61-9 1,5-Diphenyl-2-pyrazolin 
• 2038-57-5 3-Phenylpropan-1-amine 
• 84423-27-8 4a-Methoxy-7-(4-methoxy-3,6-dioxo-cyclohexa-1,4-dienyl)-4-phenyl-1-phenylamino-1,4,4a,8a-tetrahydro-quinoline-5,8-dione 
• 84423-32-5 4a,4'a-Dimethoxy-4,4'-diphenyl-1,1'-bis-phenylamino-1,4,4a,8a,1',4',4'a,8'a-octahydro-[7,7']biquinolinyl-5,8,5',8'-tetraone 
• 88246-41-7 Phenyl-{(E)-3-phenyl-3-[4-phenyl-[1,3]dithiol-(2E)-ylidene]-propenyl}-diazene 
• 88246-39-3 {(E)-3-[4,5-Dihydro-naphtho[1,2-d][1,3]dithiol-(2E)-ylidene]-3-phenyl-propenyl}-phenyl-diazene 
• 88246-40-6 [(E)-3-Naphtho[1,2-d][1,3]dithiol-(2E)-ylidene-3-phenyl-propenyl]-phenyl-diazene 
• 88246-42-8 Phenyl-{(E)-3-phenyl-3-[5-phenyl-[1,3]thiaselenol-(2Z)-ylidene]-propenyl}-diazene 
• 100983-73-1 N-[(E)-3-Phenyl-prop-2-en-(E)-ylidene]-N'-[4-(4,5,6,7-tetrahydro-benzo[1,3]dithiol-2-ylidene)-cyclohexa-2,5-dienylidene]-hydrazine; compound with perchloric acid 
• 6831-89-6 1,5-diphenyl-1H-pyrazole 
• 91-22-5 quinoline 

Relevant articles and documents

Systematic study of the fluorescent properties of cinnamaldehyde phenylhydrazone and its interactions with metals: Synthesis and photophysical evaluation

Hydrazones are organic compounds with applications in various fields of research, including fluorescent applications. In this investigation, the compound cinnamaldehyde phenylhydrazone was synthesized by condensation between cinnamaldehyde (1) and phenylh

Facile One-Pot Transformation of Primary Alcohols into 3-Aryl- and 3-Alkyl-isoxazoles and -pyrazoles

Various primary alcohols were smoothly transformed into 3-aryl- and 3-alkylisoxazoles in good yields in one pot by successive treatment with PhI(OAc) 2 in the presence of TEMPO, NH 2 OH, and then NCS, followed by reaction with alkynes in the presence of Et 3 N. Similarly, various primary alcohols were smoothly transformed into 3-aryl- and 3-alkylpyrazoles in good yields in one pot by successive treatment with PhI(OAc) 2 in the presence of TEMPO, PhNHNH 2, and then NCS and decyl methyl sulfide, followed by reaction with alkynes in the presence of Et 3 N. Thus, both 3-aryl- and 3-alkylisoxazoles, and 3-aryl- and 3-alkylpyrazoles could be prepared from readily available primary alcohols in one pot under transition-metal-free conditions.

The use of enaminones and enamines as effective synthons for MSA-catalyzed regioselective synthesis of 1,3,4-tri- And 1,3,4,5-tetrasubstituted pyrazoles

In the present work, an efficient regioselective synthesis of 1,3,4-tri- and 1,3,4,5-tetrasubstituted pyrazoles via a methanesulfonic acid (MSA)-catalyzed reaction of hydrazones with enaminones or enamines is reported. Mechanistically, the formation of the title compounds involves the [2+3] cycloaddition of hydrazones with enaminones or enamines followed by aromatization with acid and oxygen. This convenient method under mild conditions with various hydrazones, enaminones, and enamines was well-tolerated to afford products in good to excellent yields. Compared with the literature methods, this strategy has advantages such as materials that are available economically, metal-free catalysis, excellent regioselectivity, and high efficiency.