156817-68-4

Basic information

• Product Name: Imidazo[1,2-a]pyridin-8-ol, 5,6,7,8-tetrahydro- (9CI)
• Synonyms: Imidazo[1,2-a]pyridin-8-ol, 5,6,7,8-tetrahydro- (9CI)
• CAS NO: 156817-68-4
• Molecular Formula: C7H10N2O
• Molecular Weight: 138.1671
• Product Categories: AMINETERTIARY
• Mol File: 156817-68-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 365.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• PKA: 13.48±0.20(Predicted)
• CAS DataBase Reference: Imidazo[1,2-a]pyridin-8-ol, 5,6,7,8-tetrahydro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,2-a]pyridin-8-ol, 5,6,7,8-tetrahydro- (9CI)(156817-68-4)
• EPA Substance Registry System: Imidazo[1,2-a]pyridin-8-ol, 5,6,7,8-tetrahydro- (9CI)(156817-68-4)

Safety Data

• Hazardous Substances Data: 156817-68-4(Hazardous Substances Data)

Upstream product

• 24016-03-3 2-amino-3-benzyloxypyridine 
• 16867-03-1 2-amino-3-hydroxypyridine 
• 96428-16-9 8-(phenylmethoxy)imidazo[1,2-a]pyridine 
• 645-36-3 2,2-diethoxy-ethanamine 
• 19365-08-3 3-hydroxypiperidin-2-one 

Downstream Products

• 457949-09-6 6,7-dihydroimidazo[1,2-a]pyridine-8(5H)-one 

Relevant articles and documents

Condensation of Lactams with 2-Aminoacetylaldehyde Diethyl Acetal. A One-Pot Synthesis of Bicyclic Imidazoles

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Bisheterocycle substituted oxa-spiro derivative, and preparation method and medical application thereof

The invention relates to a bisheterocyclic substituted oxa-spiro derivative, and a preparation method and medical application thereof. Specifically, the invention discloses compounds of formula (I) and formula (II) or pharmaceutically acceptable salts, stereoisomers or solvates thereof, and a preparation method and application thereof. Each group in the formulas is as defined in the specificationand claims in detail.

COMPOUND, COMPOSITIONS, AND METHODS

Compounds having activity as LRRK2 inhibitors are disclosed. The compounds are of formula (I) including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.