15685-00-4Relevant academic research and scientific papers
Metal Complexes with Biologically Important Ligands, XXXV. Nickel, Cobalt, Palladium, and Platinum Complexes with Schiff Bases of α-Amino Acids. A Contribution to the Mechanism of the Akabori Reaction
Ambach, Eberhard,Beck, Wolfgang
, p. 2722 - 2737 (2007/10/02)
Various Schiff base complexes of nickel(II), cobalt(II), palladium(II), platinum(II), and platinum (IV) 3 - 6, 8 - 10 have been prepared from glycinatometal complexes and amide acetals. (N,N-Dimethylbenzylamine-C2,N)glycinatopalladium(II) (2a) reacts with formaldehyde to give the corresponding N-methylene Schiff base complex 11.Serine or threonine is formed from 11 and RCHO (R = H, Me) after reductive elimination of palladium using H2/Pd-C.By isolation of 11 it is confirmed that the Akabori reaction proceeds initially by attack of the aldehyde at the N-atom of the glycinate ligand.The template reaction of K2PtCl4 or Na2PdCl4 and amino acids or amino acid derivatives, respectively, with pyruvate affords a series of N-(1-carboxyethylidene) Schiff base complexes 13 - 16.The IR and NMR data ( 1H, 13C, 195Pt) of the compounds are reported.
