1568951-82-5Relevant academic research and scientific papers
Rhodium(III)-Catalyzed three-component reaction of imines, alkynes, and Aldehydes through C-H activation
Huang, Ji-Rong,Song, Qiang,Zhu, Yu-Qin,Qin, Liu,Qian, Zhi-Yong,Dong, Lin
, p. 16882 - 16886 (2014)
An efficient rhodium(III)-catalyzed tandem three-component reaction of imines, alkynes and aldehydes through C-H activation has been developed. High stereo- and regioselectivity, as well as good yields were obtained in most cases. The simple and atom-economical approach offers a broad scope of substrates, providing polycyclic skeletons with potential biological properties.
Enantioselective Access to Spirocyclic Sultams by Chiral Cpx-Rhodium(III)-Catalyzed Annulations
Pham, Manh V.,Cramer, Nicolai
supporting information, p. 2270 - 2273 (2016/02/14)
Chiral spirocyclic sultams are a valuable compound class in organic and medicinal chemistry. A rapid entry to this structural motif involves a [3+2] annulation of an N-sulfonyl ketimine and an alkyne. Although the directing-group properties of the imino group for C-H activation have been exploited, the developments of related asymmetric variants have remained very challenging. The use of rhodium(III) complexes equipped with a suitable atropchiral cyclopentadienyl ligand, in conjunction with a carboxylic acid additive, enables an enantioselective and high yielding access to such spirocyclic sultams.
Cp?CoIII-Catalyzed C-H Alkenylation/Annulation to Afford Spiro Indenyl Benzosultam
Liu, Hui,Li, Jie,Xiong, Miao,Jiang, Jijun,Wang, Jun
, p. 6093 - 6099 (2016/07/26)
Cp?CoIII-catalyzed tandem inert C-H alkenylation/annulation of N-sulfonyl ketimines with alkynes is revealed. A series of spiro indenyl benzosultams were facilely prepared in good yields under mild reaction conditions.
Catalytic [3 + 2] annulation of ketimines with alkynes via C-H activation by a cationic iridium(cod) complex
Nagamoto, Midori,Nishimura, Takahiro
supporting information, p. 6274 - 6277 (2014/06/09)
[3 + 2] Annulation of ketimines with internal and terminal alkynes proceeded via C-H activation to give aminoindene derivatives in high yields, which is catalyzed by a cationic iridium complex coordinated with 1,5-cyclooctadiene (cod). This journal is the Partner Organisations 2014.
Rhodium-catalyzed spirocyclic sultam synthesis by [3+2] annulation with cyclic N-sulfonyl ketimines and alkynes
Dong, Lin,Qu, Chuan-Hua,Huang, Ji-Rong,Zhang, Wei,Zhang, Qian-Ru,Deng, Jin-Gen
, p. 16537 - 16540 (2014/01/17)
An efficient RhIII-catalyzed [3+2] annulation of cyclic N-sulfonyl ketimines with internal alkynes was disclosed in the presence of catalytic amounts of AgSbF6 to form synthetically challenging spirocyclic sultams in high yield under
