156947-99-8Relevant articles and documents
VINYL ETHER HYDROLYSIS. 30. EFFECT OF β-CARBOXY AND β-CARBOMETHOXY SUBSTITUTION
Kresge, A. J.,Ubysz, D.
, p. 316 - 322 (1994)
Rates of hydrolysis of the vinyl ether functional groups of (Z)- and (E)-β-methoxyacrylic acid and (Z)- and (E)-β-methoxymethacrylic acid and their methyl esters were measured in aqueous perchloric acid solution.Additional rate measurements were also made for one substrate, (Z)-β-methoxymethacrylic acid, in buffer solutions down to pH 7, and a rate profile was constructed.The results show that the β-carboxy and β-carbomethoxy substituents produce strong rate retardations, ranging from 2000- to 25 000-fold, for both Z- and E-isomers in both the acrylic and methacrylic acid series.The rate profile for (Z)-β-methoxymethacrylic acid indicates that ionization of this substrate to the carboxylate ion form raises the rate of hydrolysis by a factor of 240.It is argued that this difference in reactivity of ionized and non-ionized forms of the substrate is due to conjugative and inductive effects of the substituents, rather than β-lactone formation as suggested in an earlier observation of the same phenomenon in a different system.
Isobenzofurans as Synthetic Intermediates: Synthesis and Biological Activity of 8-epi-(–)-Ajudazol B
Adair, Liam,Egan, Ben A.,Pearson, Colin M.,Lopez-Gonzalez, Ricardo,Kuchar, Michal,Mendoza-Mendoza, Artemio,Prunet, Jo?lle,Marquez, Rodolfo
supporting information, p. 6661 - 6672 (2020/10/15)
Ajudazol B is a polyketide secondary metabolite, isolated from the myxobacterium Chondromyces crocatus, that exhibits potent biological activity. Herein, we report a convergent total synthesis of 8-epi-(–)-ajudazol B. The key step is a regio-selective alk
PANTETHEINE DERIVATIVES AND USES THEREOF
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Paragraph 2121, (2020/06/19)
The present disclosure relates to compounds of Formula (I), (II), or (II'): (I), (II), (II'), and pharmaceutically acceptable salts or solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the compounds and therapeutic and diagnostic uses of the compounds and pharmaceutical compositions.
Iridium-catalyzed asymmetric hydrogenation of vinyl ethers
Zhu, Ye,Burgess, Kevin
supporting information; experimental part, p. 979 - 983 (2009/05/30)
A carbene-oxazoline catalyst 1 proved to be an effective catalyst for reduction of an enol ether that the literature suggested could not be hydrogenated effectively by P,N-Ir catalysts. Thus, a series of ester and alcohol substrates were hydrogenated using catalyst 1. Good to excellent enantioselectivities and high conversions were obtained.
