1571082-65-9Relevant academic research and scientific papers
Enantioselective Lewis base catalyzed phosphonyldifluoromethylation of allylic fluorides using a: C -silyl latent pronucleophile
Zi, You,Lange, Markus,Vilotijevic, Ivan
, p. 5689 - 5692 (2020/06/19)
The first enantioselective phosphonyldifluoromethylation is enabled by the use of diethyl (difluoro(trimethylsilyl)-methyl)phosphonate reagent as a latent pronucleophile in the Lewis base catalyzed substitution of allylic fluorides. The reaction proceeds
Synthesis of chiral (tetrazolyl)methyl-containing acrylates via silicon-induced organocatalytic kinetic resolution of Morita-Baylis-Hillman fluorides
Nishimine, Takayuki,Taira, Hiromi,Mori, Satoru,Matsubara, Okiya,Tokunaga, Etsuko,Akiyama, Hidehiko,Soloshonok, Vadim A.,Shibata, Norio
supporting information, p. 1128 - 1131 (2017/02/05)
Reported herein is a new approach for the asymmetric installation of a (tetrazolyl)methyl group via Si/F activation using organocatalytic kinetic resolution of racemic MBH-fluorides.
Kinetic resolution of allyl fluorides by enantioselective allylic trifluoromethylation based on silicon-assisted c-F bond cleavage
Nishimine, Takayuki,Fukushi, Kazunobu,Shibata, Naoyuki,Taira, Hiromi,Tokunaga, Etsuko,Yamano, Akihito,Shiro, Motoo,Shibata, Norio
, p. 517 - 520 (2014/01/23)
Two birds, one stone! The first kinetic resolution of allyl fluorides was achieved by the development of an organocatalyzed enantioselective allylic trifluoromethylation. Two kinds of chiral fluorinated compounds, which incorporate C-F and C-CF3 units, respectively, can thus be accessed by a single transformation.
