1572-92-5Relevant articles and documents
Preparation method of 1,4-butanediol and dicarboxylic acid ester thereof
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Paragraph 0054; 0055, (2019/10/01)
The invention relates to a preparation method of 1,4-butanediol and a dicarboxylic acid ester thereof. Specifically, the preparation method of 1,4-butanediol and the dicarboxylic acid ester thereof comprises the following steps: performing hydrodecarbonylation esterification ring-opening on a furoic acid compound, a trifluoromethanesulfonate, a hydrogenation catalyst in a carboxylic acid solvent to obtain a 1,4-butanediol dicarboxylic acid ester. The method has the characteristics of simple process, easy purification, high yield, green safety, and the like, and is suitable for large-scale industrial production.
PROCESS FOR PREPARING 1,4-BUTANDIOL MONONITRATE
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Page/Page column 25-27; 28, (2009/03/07)
The present invention relates to a process for the preparation of 1,4-butanediol mononitrate as intermediate for large scale preparation of high purity nitrooxybutyl ester of pharmaceutically active compounds.
Highly Selective Monoacylation of Symmetric Diols Catalyzed by Metal Sulfates Supported on Silica Gel
Nishiguchi, Takeshi,Kawamine, Katsumi,Ohtsuka, Tomoko
, p. 312 - 316 (2007/10/02)
Several 1,α-diols, ranging from 1,2-ethanediol to 1,16-hexadecanediol, were monoacylated with high selectivity by reaction with esters in the presence of metal sulfates or hydrogen sulfates, like Ce(SO4)2 and NaHSO4, supported on silica gel.Symmetrical secondary diols were also selectively monoformylated, by reaction with ethyl formate.This method of selective esterification is simple and practical.The yield of monoester depends upon both the composition and the volume of the solvent (an ester/alkane mixture).Unsupported NaHSO4 also catalyzed monoacylation, but the selectivity was less than in monoacylations catalyzed by the supported reagent.The selectivity can be explained by the following reasons: (1) monoacylated products are formed selectively because the diol, but not the monoester, is preferentially adsorbed on the surface of the catalysts, where esterification then occurs, and (2) thin diol layers are formed on the surface of the catalysts due to limited solubility of the diols in the solvent.