15722-67-5Relevant articles and documents
An efficient chemoenzymatic approach to (S)-γ-fluoroleucine ethyl ester
Limanto, John,Shafiee, Ali,Devine, Paul N.,Upadhyay, Veena,Desmond, Richard A.,Foster, Bruce R.,Gauthier Jr., Donald R.,Reamer, Robert A.,Volante
, p. 2372 - 2375 (2007/10/03)
(Chemical Equation Presented) An asymmetric synthesis of (S)-γ-fluoroleucine ethyl ester 1 is described. The key transformation involves a lipase-catalyzed dynamic ring-opening of 2-(3-butenyl)azlactone 7b with EtOH to give amide ester (S)-6b in 84% enant
Tritiated Peptides. Part 13. Synthesis of 2>- and 6>-Locust Adipokinetic Hormone
Hardy, Paul M.,Sheppard, Paul W.,Brundish, Derek E.,Wade, Roy
, p. 731 - 734 (2007/10/02)
The synthesis of 2>- and 6>-locust adipokinetic hormones by the catalytic tritiation of 2>-(ΔLeu2-) and 6>-(ΔPro6-) precursors is described.The products had specific radioactivities of 115 and 12.1 Ci mmol-1 respectively.The distribution of isotope in the former was investigated by 3H n.m.r. spectroscopy which confirmed the conclusions from 2H n.m.r. spectroscopy of catalytically deuterated N-acetyl-4,5-dehydroleucine.It was concluded that the δ-methyl groups and the γ-methinyl group of leucine are the only tritiated positions in the molecule.