15722-67-5

Upstream product

• 848949-89-3 4-(2-fluoro-2-methyl-propyl)-2-phenyl-4H-oxazol-5-one 
• 848949-86-0 ethyl-2-(diphenylmethyleneamino)-4-fluoro-4-methylpentanoate 
• 848949-87-1 2-benzoylamino-4-fluoro-4-methyl-pentanoic acid 
• 848949-91-7 (S)-2-Benzoylamino-4-fluoro-4-methyl-pentanoic acid ethyl ester 
• 152861-37-5 (3R,5S)-4-Benzoyl-5-tert-butyl-1,1-dimethyl-6-oxa-4-aza-spiro[2.4]heptan-7-one 
• 28024-78-4 DL-γ,δ-didehydroleucine 

Downstream Products

• 58178-41-9 L-α-Benzoylamino-γ-methyl-γ-valeriansaeurelacton 
• 77694-20-3 4,4-dimethyl-2-(2,2,2-trifluoroacetamido)butyrolactone 
• 77443-33-5 L-γ-Methyl-α-(4-nitrobenzyloxycarbonylamino)-γ-valeriansaeurelacton 
• 77443-36-8 L-γ-Methyl-α-trifluoracetylamino-γ-valeriansaeurelacton 
• 77443-39-1 L-α-(2,4-Dinitrophenylamino)-γ-methyl-γ-valeriansaeurelacton 
• 77443-38-0 L-γ-Methyl-α-tritylamino-γ-valeriansaeurelacton 
• 77443-41-5 L-γ-Methyl-α-(p-tolylsulfonylamino)-γ-valeriansaeurelacton 

Relevant academic research and scientific papers

An efficient chemoenzymatic approach to (S)-γ-fluoroleucine ethyl ester

(Chemical Equation Presented) An asymmetric synthesis of (S)-γ-fluoroleucine ethyl ester 1 is described. The key transformation involves a lipase-catalyzed dynamic ring-opening of 2-(3-butenyl)azlactone 7b with EtOH to give amide ester (S)-6b in 84% enant

Synthesis of (R)- and (S)-2,3-Methanovaline from (2S)-N-Benzoyl-2-tert-butyl-4-methylene-1,3-oxazolidin-5-one

The reaction of (2S)-N-benzoyl-2-tert-butyl-4-methylene-1,3-oxazolidin-5-one (9) with isopropylidenetriphenylphosphorane at room temperature gives the corresponding cis and trans spirocyclopropane derivatives 10 in ca. 1:1 ratio.After separation of both diastereomers, by recrystallization and flasch chromatography, and further acid hydrolysis, enantiomerically pure (R)- and (S)-2,3-methanovaline 11 are obtained.

Tritiated Peptides. Part 13. Synthesis of 2>- and 6>-Locust Adipokinetic Hormone

The synthesis of 2>- and 6>-locust adipokinetic hormones by the catalytic tritiation of 2>-(ΔLeu2-) and 6>-(ΔPro6-) precursors is described.The products had specific radioactivities of 115 and 12.1 Ci mmol-1 respectively.The distribution of isotope in the former was investigated by 3H n.m.r. spectroscopy which confirmed the conclusions from 2H n.m.r. spectroscopy of catalytically deuterated N-acetyl-4,5-dehydroleucine.It was concluded that the δ-methyl groups and the γ-methinyl group of leucine are the only tritiated positions in the molecule.