15724-70-6

Usage

Uses

Used in Organic Synthesis:
N,N'-acridine-3,6-diyldi(acetamide) is utilized as a key building block in organic synthesis for the preparation of a variety of chemical derivatives and analogs. Its structural properties facilitate the creation of new compounds with diverse applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, N,N'-acridine-3,6-diyldi(acetamide) is employed as a precursor for the development of pharmaceuticals. Its ability to be modified and incorporated into different molecular frameworks makes it instrumental in the design of new drugs.
Used in Antimicrobial Applications:
N,N'-acridine-3,6-diyldi(acetamide) is used as an antimicrobial agent, demonstrating effectiveness against various microorganisms. Its potential in this area is attributed to its ability to interfere with essential cellular processes in bacteria and other pathogens, thereby exhibiting inhibitory effects.
Used in Antitumor Applications:
N,N'-acridine-3,6-diyldi(acetamide) is also used as an antitumor agent, showing promise in the fight against cancer. Its biological activity has been studied for its potential to impact tumor growth and progression, offering a new avenue for cancer treatment.
Used in Antiviral Applications:
N,N'-acridine-3,6-diyldi(acetamide) is utilized in antiviral applications, where it has displayed the capacity to inhibit viral replication and infectivity. This makes it a candidate for further research and development in the creation of antiviral medications.

Upstream product

• 108-24-7 acetic anhydride 
• 92-62-6 proflavine 
• 75-36-5 acetyl chloride 
• 101-77-9 4,4'-diamino diphenyl methane 
• 26946-33-8 4,4'-methylenebis(m-nitroaniline) 

Downstream Products

• 86-40-8 acriflavine 

Relevant academic research and scientific papers

New α,ω-Diamido and α,ω-Diamino Mono- and Bi-Bridged Acridine Dimers

A novel set of dimers derived from 9-amino acridine was prepared and characterized by 1H and 13C NMR.These derivatives are bridged at several different positions of the heterocyclic moieties, by the way of α,ω-diamide or α,ω-diamino side-chains.Additionally the preparation of some bi-bridged compounds was achieved. Keywords. 9-Amino-acridine; Mono-bridged dimers; Bi-bridged dimers;

Synthesis and antileishmanial activity of 6-mono-substituted and 3,6-di-substituted acridines obtained by acylation of proflavine

Two new series of diaminoacridinic derivatives obtained from proflavine and N-(6-amino-3-acridinyl)acetamide were synthesised and assessed for their cytotoxic and antileishmanial activities. Two compounds, N-[6-(acetylamino)-3-acridinyl]acetamide and N-[6-(benzoylamino)-3-acridinyl]benzamide demonstrated highly specific antileishmanial properties against the intracellular amastigote form of the parasite. Structure-activity relationships established that the antiproliferative activity against human cells was greatly enhanced by the presence of a benzoylamino group in 6-mono-substituted acridines, while the presence of two acetylamino or benzoylamino groups in 3,6-di-substituted acridines strongly increased the specificity of the molecules for Leishmania parasite, suggesting that symmetric conformations could preferentially interfere with Leishmania metabolism.

Photo-inducible cytotoxic and clastogenic activities of 3,6-di-substituted acridines obtained by acylation of proflavine

The cytotoxicity and photo-enhanced cytotoxicity of a series of 18 3,6-di-substituted acridines were evaluated on both tumour CHO cells and human normal keratinocytes, and compared to their corresponding clastogenicity as assessed by the micronucleus assa