157240-02-3Relevant academic research and scientific papers
α7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF-I
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, (2014/02/16)
The present invention relates to chemical compounds of formula (I), with the substituents as described in the specification, useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (α7 nAChR). The invention also relates to the use of these compounds in the treatment or prevention of a broad range of diseases in which the positive modulation of α7 nAChR is advantageous, including neurodegenerative and neuropsychiatric diseases and also neuropathic pain and inflammatory diseases.
Conformation of N-Cyclopropylcarbonylureas. Solvent Polarity Dependent Chemical Shifts
Kohmoto, Shigeo,Kasimura, Hideaki,Nishio, Takehiko,Iida, Ikuo,Kishikawa, Keiki,et al.
, p. 1565 - 1568 (2007/10/02)
The relation between solvent polarity and the chemical shifts of two diastereoisomeric N-cyclopropylcarbonylureas 1 and 2 was examined to elucidate their conformations in solution.In non-polar solvents, where intramolecular hydrogen bonding was playing an important role, their conformations were estimated to be similar to that of 1 in its crystalline state.
