83217-08-7Relevant articles and documents
Structure-activity relationships of 2, 4-disubstituted pyrimidines as dual ERα/VEGFR-2 ligands with anti-breast cancer activity
Luo, Guoshun,Tang, Zhichao,Lao, Kejing,Li, Xinyu,You, Qidong,Xiang, Hua
, p. 783 - 795 (2018/04/02)
Both ERα and VEGFR-2 are important targets for cancer therapies. Here a series of 2, 4-disubstituted pyrimidine derivatives were designed, synthesized and evaluated as dual ERα/VEGFR-2 ligands. Most of the derivatives exhibited potent activities in both e
Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
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Example Pr3, (2008/06/13)
This invention is directed to aryl and heterocyclyl substituted pyrimidine derivatives selected from the following formulae: wherein Z1, Z2, R1, R2, R3, R4, R5and R6are defined herein. These compounds are useful as anti-coagulants.