157276-72-7

Basic information

• Product Name: 3-Pyridinecarboxylicacid,2-(propylamino)-,methylester(9CI)
• Synonyms: 3-Pyridinecarboxylicacid,2-(propylamino)-,methylester(9CI)
• CAS NO: 157276-72-7
• Molecular Formula: C₁₀H₁₄N₂O₂
• Molecular Weight: 194.23
• Product Categories: AMINOACID
• Mol File: 157276-72-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Pyridinecarboxylicacid,2-(propylamino)-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxylicacid,2-(propylamino)-,methylester(9CI)(157276-72-7)
• EPA Substance Registry System: 3-Pyridinecarboxylicacid,2-(propylamino)-,methylester(9CI)(157276-72-7)

Safety Data

• Hazardous Substances Data: 157276-72-7(Hazardous Substances Data)

Upstream product

• 2942-59-8 2-chloronicotinic acid 
• 49609-84-9 2-Chloronicotinoyl chloride 
• 107-10-8 propylamine 
• 40134-18-7 methyl 2-chloropyridine-3-carboxylate 

Downstream Products

• 150869-58-2 2-{Propyl-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-nicotinic acid methyl ester 
• 141887-34-5 A 81988 
• 151322-75-7 methyl 2-amino>pyridine-3-carboxylate 

Relevant articles and documents

2-(Alkylamino)nicotinic Acid and Analogs. Potent Angiotensin II Antagonists

A series of pyridines and other six-membered ring heterocycles connected to a biphenyltetrazole with a-CH2-NR'-link (1) were discovered to be potent angiotensin II antagonists.In the pyrimidine carboxylic acid series (W = CR, X = N, Y = CH, Z = COOH), compounds with an alkyl group (R') on the exocyclic nitrogen were much more potent than compounds with an alkyl group (R) on the heterocyclic ring.The corresponding pyridine, pyridazine, pyrazine, and 1,2,4-triazine carboxylic acids also showed potent in vitro angiotensin II antagonism.The pyridine (W, X, Y = CH, Z = COOH, R' = n-C3H7) demonstrated potent in vitro activity (pA2 = 10.10, rabbit aorta, and Ki = 0.61 nM, receptor binding in rat liver) as well as exceptional oral antihypertensive activity and bioavailability.Any nonacidic replacement for the carboxylic acid was detrimental for activity.