157339-06-5Relevant academic research and scientific papers
Α-hydroxyacid salt
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Paragraph 0049-0052, (2018/02/14)
PROBLEM TO BE SOLVED: To provide a novel method for manufacturing a salt of α-hydroxy acid as an intermediate for synthesizing α-hydroxy acid derivatives which promotes carboxylation promptly by the COsupplementation reaction even if the substrate having
Synthesis of enantioenriched α-(hydroxyalkyl)-tri-n-butylstannanes
He, Anyu,Falck, John R.
, p. 6586 - 6589 (2009/03/12)
(Chemical Equation Presented) Li and Mg are pesky: A catalytic asymmetric synthesis of α-(hydroxyalkyl)-tri-n-butylstannanes (1) in good to excellent yields and enantioselectivities was achieved (see scheme; PG=protecting group; L=chiral ligand). Compound 1 was isolated as an ester or thiocarbamate, and the reagent was prepared from equimolar amounts of nBu3SnH and Et2Zn in dimethoxyethane. Conditions employing lithium or magnesium ions suppress enantioselectivity.
Stereospecific palladium/copper cocatalyzed cross-coupling of α-alkoxy- and α-aminostannanes with acyl chlorides
Ye,Bhatt,Falck
, p. 1 - 5 (2007/10/02)
Stille-type cross-coupling between α-alkoxy(amino)stannanes and acyl chlorides affords α-hetero-substituted ketones in moderate to good yields when cocatalyzed by Pd and Cu(I) salts. The reaction is applicable to a wide range of tin compounds, especially those bearing α-electron-withdrawing groups such as benzoyloxy or acetyloxy, although some ethers (e.g., MOM) are also satisfactory. Aromatic acid chlorides give the best yields. Coupling of chiral α-alkoxystannanes, readily available by BINAL-H asymmetric reduction of acylstannanes, proceeds with retention of configuration.
