1574468-08-8Relevant academic research and scientific papers
Antioxidant activity and interaction with DNA and albumins of zinc-tolfenamato complexes. Crystal structure of [Zn(tolfenamato) 2(2,2′-dipyridylketoneoxime)2]
Tarushi, Alketa,Totta, Xanthippi,Papadopoulos, Athanasios,Kljun, Jakob,Turel, Iztok,Kessissoglou, Dimitris P.,Psomas, George
, p. 187 - 196 (2014)
The zinc(II) complex of the non-steroidal anti-inflammatory drug tolfenamic acid (=Htolf) in the presence of 2,2′-dipyridylketone oxime (=Hpko) as a N,N′-donor heterocyclic ligand, [Zn(tolf-O)2(Hpko-N,N′) 2]·MeOH (=1·MeOH), has been synthesized and characterized by physicochemical techniques including X-ray crystallography. The complex exhibits good binding affinity to human or bovine serum albumin with high binding constant values. Complex 1 and previously reported Zn-tolfenamato complexes were tested for their free radical scavenging activity and in vitro inhibitory activity against soybean lipoxygenase and exhibited significant activity with [Zn(tolf)2(1,10-phenantroline)] being the most active compound. The complexes interact with calf-thymus (CT) DNA via intercalation, and can displace the DNA-bound ethidium bromide with 1 exhibiting the highest binding constant to CT DNA.
