157459-19-3

Upstream product

• 121587-38-0 2-(2-trimethylsilyl-3-methoxyphenyl)ethylamine 
• 113337-60-3 (2-Chloromethyl-6-methoxy-phenyl)-trimethyl-silane 
• 121587-39-1 2,2,2-Trifluoro-N-[2-(3-methoxy-2-trimethylsilanyl-phenyl)-ethyl]-acetamide 
• 121587-37-9 (3-Methoxy-2-trimethylsilanyl-phenyl)-acetonitrile 
• 159411-78-6 2-(2-bromo-3-methoxyphenyl)ethylamine 
• 128828-87-5 (2-bromo-3-methoxyphenyl)acetonitrile 
• 128828-86-4 2-bromo-1-(bromomethyl)-3-methoxybenzene 
• 121587-42-6 N-{2-[2-((4R,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carbonyl)-3-methoxy-phenyl]-ethyl}-2,2,2-trifluoro-acetamide 
• 121587-41-5 N-(2-{2-[((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-3-methoxy-phenyl}-ethyl)-2,2,2-trifluoro-acetamide 
• 157543-62-9 (S)-1-((1S,2S)-3-Benzyloxy-1,2-dihydroxy-propyl)-8-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester 
• 121587-40-4 N-trifluoroacetyl-2-(2-bromo-3-methoxyphenyl)ethylamine 
• 38197-43-2 2-bromo-3-methylanisole 
• 157543-63-0 (S)-1-((4S,5S)-5-Benzyloxymethyl-2-thioxo-[1,3]dioxolan-4-yl)-8-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester 

Downstream Products

• 121587-49-3 (R)-1-((E)-3-Benzyloxy-propenyl)-8-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline 

Relevant academic research and scientific papers

Synthetic studies on quinocarcin and its related compounds. 1. Synthesis of enantiomeric pairs of the ABE ring systems of quinocarcin

Enantiomeric pairs of the ABE ring system (5 and ent-5) and its analogues (6, ent-6, 7, and ent-7) of quinocarcin (1), a prominent antitumor antibiotic, were synthesized in >95% ee with an aim to elucidate structure-activity relationships of 1. The key st

CHIRAL SYNTHESIS OF THE ABE-RING SYSTEM OF QUINOCARCIN

An enantiomeric pair of the ABE-ring systems of quinocarcin (1), a potent antitumor antibiotic, was synthesized in > 95percent ee by employing each enantiomer of 4-O-benzyl-2,3-O-isopropylidene-threose as a chiral auxiliary and featuring novel stereoselective reduction of the 3,4-dihydroisoquinoline derivative.