157485-26-2Relevant academic research and scientific papers
Expedient Synthesis of Ketones via N-Heterocyclic Carbene/Nickel-Catalyzed Redox-Economical Coupling of Alcohols and Alkynes?
Li, Yu-Qing,Li, Feng,Shi, Shi-Liang
supporting information, p. 1035 - 1039 (2020/06/30)
An N-heterocyclic carbene/nickel-catalyzed direct coupling of alcohols and internal alkynes to form α-branched ketones has been developed. This methodology provides a new approach to afford branched ketones, which are difficult to access through the hydroacylation of simple internal alkenes with aldehydes. This redox-neutral and redox-economical coupling is free from any oxidative or reductive additives as well as stoichiometric byproducts. These reactions convert both benzylic and aliphatic alcohols and alkynes, two basic feedstock chemicals, into various α-branched ketones in a single chemical step.
Rhodium-catalyzed ketone methylation using methanol under mild conditions: Formation of α-branched products
Chan, Louis K. M.,Poole, Darren L.,Shen, Di,Healy, Mark P.,Donohoe, Timothy J.
, p. 761 - 765 (2014/01/23)
The rhodium-catalyzed methylation of ketones has been accomplished using methanol as the methylating agent and the hydrogen-borrowing method. The sequence is notable for the relatively low temperatures that are required and for the ability of the reaction system to form α-branched products with ease. Doubly alkylated ketones can be prepared from methyl ketones and two different alcohols by using a sequential one-pot iridium- and rhodium-catalyzed process. Uniquely effective for making branched alkyl products from ketones (see scheme): The scope of the presented reaction includes aromatic and aliphatic ketones and consecutive one-pot double alkylation reactions to provide a convenient route to branched ketones from simple methyl ketones. A brief study into the mechanism of the reaction has given evidence for an aldol-based reaction pathway.
Photoreactivity of α-Tetrasubstituted Arylketones: Production and Asymmetric Tautomerization of Arylenols
Henin, Francoise,M'Boungou-M'Passi, Athanase,Muzart, Jacques,Pete, Jean-Pierre
, p. 2849 - 2864 (2007/10/02)
In the presence of catalytic amounts of optically active aminoalcohols, the irradiation of α-disubstituted indanones, tetralones and propiophenones bearing at least one hydrogen in the γ-position led to Norrish type II cleavage compounds which were obtained with enantiomeric excesses reaching 89percent.The influence of the reaction conditions (temperature, wavelength of the UV light and nature of the aminoalcohol) has been analyzed.
