15753-55-6Relevant academic research and scientific papers
Fe-Catalyzed enaminone synthesis from ketones and amines
Wu, Wenfeng,Wang, Zhuxian,Shen, Qun,Liu, Qiang,Chen, Huoji
supporting information, p. 6753 - 6756 (2019/07/22)
We have developed an iron-catalyzed direct olefination for enaminone synthesis, with saturated ketones as a source of olefins. This direct ketone β-functionalization reaction has readily available starting materials and a wide range of substrates and requires mild reaction conditions.
Intermolecular Multiple Dehydrogenative Cross-Couplings of Ketones with Boronic Acids and Amines via Copper Catalysis
Wang, Tianzhang,Chen, Guowei,Lu, Yu-Jing,Chen, Qian,Huo, Yanping,Li, Xianwei
supporting information, p. 3886 - 3892 (2019/07/19)
An efficient and versatile oxidative coupling reaction was developed for the synthesis of valuable β-functionalized unsaturated ketones and meta-substituted phenols. In the case of intramolecular reactions, achieving rapid molecular complexity through multiple dehydrogenative couplings is already a well-established strategy. Herein, we report an intermolecular multiple dehydrogenative coupling between ketones and nucleophilic amines or boronic acids using inexpensive copper(I) oxide as a catalyst. This method provides a facile access to highly desirable chemical products such as α,β-unsaturated ketones, enaminones, and synthetically relevant meta-substituted phenols. (Figure presented.).
Silver-catalyzed efficient synthesis of enaminones from propargyl alcohols and amines
Li, Mengshun,Fang, Dongmei,Geng, Feng,Dai, Xianping
supporting information, p. 4747 - 4749 (2017/11/28)
Enaminones are used as the key intermediates to construct heterocyclic compounds with various bioactivities. In this study, a simple and efficient approach for the synthesis of enaminones via amination of propargyl alcohols was developed. Under the catalysis of Ag2CO3, the reaction proceeded smoothly to afford the desired products in good yields. Preliminary mechanism experiments showed that Ag2CO3 played an essential role in the procedure of the reaction.
Copper-catalyzed intramolecular oxidative amination of enaminone C-H bond for the synthesis of imidazo[1,2-a]pyridines
Wan, Jie-Ping,Hu, Deqing,Liu, Ying,Li, Luyao,Wen, Chengping
supporting information, p. 2880 - 2883 (2016/06/14)
The intramolecular C-N bond forming cross coupling reactions on the enaminones has been achieved for the synthesis of imidazole[1,2-a]pyridines via copper-catalyzed C(sp2)-H amination. This protocol provides a new route for the synthesis of 2-u
