157543-67-4

Basic information

• Product Name: 5'-O-(4,4'-dimethoxytrityl)-N-acetyl-2'-deoxycytidine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite
• CAS NO: 157543-67-4
• Molecular Weight: 771.85
• Mol File: 157543-67-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5'-O-(4,4'-dimethoxytrityl)-N-acetyl-2'-deoxycytidine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(4,4'-dimethoxytrityl)-N-acetyl-2'-deoxycytidine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite(157543-67-4)
• EPA Substance Registry System: 5'-O-(4,4'-dimethoxytrityl)-N-acetyl-2'-deoxycytidine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite(157543-67-4)

Safety Data

• Hazardous Substances Data: 157543-67-4(Hazardous Substances Data)

Upstream product

• 951-77-9 2'-Deoxycytidine 
• 32909-05-0 N⁴-acetyl-2'-deoxycytidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 124482-92-4 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine 
• 100898-63-3 5’-O-(4,4’dimethoxytrityl)-N4-(acetyl)-2'-deoxycytidine 

Downstream Products

• 1422956-11-3 (2R,3S,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl((2R,3S,4R,5R)-4-azido-5-(6-benzamido-9H-purin-9-yl)-3-(tert-butyldimethylsilyloxy)tetrahydrofuran-2-yl)methyl 2-cyanoethyl phosphate 
• 140613-57-6 5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite] 

Relevant articles and documents

Fast Cleavage and Deprotection of Oligonucleotides

We have developed methylamine/ammonia as a fast cleavage and deprotection reagent which effects complete cleavage of oligonucleotides from the solid support in 5 min at room temperature and complete deprotection in 5 min at 65 deg C.The problem of transamination side products formation, faced with the commonly used dCbz (10percent side product) upon treatment with methylamine/ammonia, has been sucessfully solved by the use of dCac (0.0percent side product).DMT dCac phosphoramidite-methylamine/ammonia system furnished oligonucleotides in equal or superior quality as compared to the other systems.