1576-13-2

Basic information

• Product Name: Phenol, 4,4'-propylidenebis-
• CAS NO: 1576-13-2
• Molecular Formula: C15H16O2
• Molecular Weight: 228.291
• Mol File: 1576-13-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Phenol, 4,4'-propylidenebis-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 4,4'-propylidenebis-(1576-13-2)
• EPA Substance Registry System: Phenol, 4,4'-propylidenebis-(1576-13-2)

Safety Data

• Hazardous Substances Data: 1576-13-2(Hazardous Substances Data)

Upstream product

• 123-38-6 propionaldehyde 
• 108-95-2 phenol 
• 18922-13-9 diethylstilbesterol pinacolone 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 645-56-7 4-n-Propylphenol 
• 1092362-45-2 4-(1-(4-hydroxyphenyl)propyl)phenyl acetate 
• 539-12-8 4-Propenyl-phenol 
• 108-95-2 phenol 
• 4792-39-6 1,1-bis(4-methoxyphenyl)propane 

Relevant articles and documents

Eco-friendly Solvent-free Route to Alkyl- and Aryl-Bisphenols Catalyzed by Perchloric Acid-Silica

-

A case of remote asymmetric induction in the peptide-catalyzed desymmetrization of a bis(phenol)

We report a catalytic approach to the synthesis of a key intermediate on the synthetic route to a pharmaceutical drug candidate in single enantiomer form. In particular, we illustrate the discovery process employed to arrive at a powerful, peptide-based asymmetric acylation catalyst. The substrate this catalyst modifies represents a remarkable case of desymmetrization, wherein the enantiotopic groups are separated by nearly a full nanometer, and the distance between the reactive site and the pro-stereogenic element is nearly 6 A. Differentiation of enantiotopic sites within molecules that are removed from the prochiral centers by long distances presents special challenges to the field of asymmetric catalysis. As the distance between enantiotopic sites increases within a substrate, so too may the requirements for size and complexity of the catalyst. The approach presented herein contrasts enzymatic catalysts and small-molecule catalysts for this challenge. Ultimately, we report here a synthetic, miniaturized enzyme mimic that catalyzes a desymmetrization reaction over a substantial distance. In addition, studies relevant to mechanism are presented, including (a) the delineation of structure-selectivity relationships through the use of substrate analogs, (b) NMR experiments documenting catalyst-substrate interactions, and (c) the use of isotopically labeled substrates to illustrate unequivocally an asymmetric catalyst-substrate binding event.

Method for manufacturing bisphenol

A method for manufacturing bisphenol by reacting phenols and ketones, characterized (1) in that an alkali metal compound and/or alkaline earth metal compound is added to bisphenol obtained by reacting a phenol and a ketone, and (2) in that the basicity of the bisphenol is adjusted so as to be equivalent to an amount of 1 × 10-8to 1 × 10-6moles of bisphenol as disodium salt with respect to 1 mole of bisphenol provides a bisphenol in which there is no residue of the organic catalysts ordinarily used in manufacturing bisphenol, so that byproducts are not produced during purification, allowing bisphenol with outstanding color tone, thermal resistance, etc., to be obtained.