157652-28-3

Basic information

• Product Name: METHYL 2-BROMOMETHYL-4-FLUORO-BENZOATE
• Synonyms: METHYL 2-BROMOMETHYL-4-FLUORO-BENZOATE;Benzoic acid, 2-(bromomethyl)-4-fluoro-, methyl ester;2-Bromomethyl-4-fluoro-benzoic acid methyl ester
• CAS NO: 157652-28-3
• Molecular Formula: C₉H₈BrFO₂
• Molecular Weight: 247.07
• Mol File: 157652-28-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 291.6°C at 760 mmHg
• Flash Point: 130.1°C
• Appearance: /
• Density: 1.534g/cm³
• Vapor Pressure: 0.00193mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: METHYL 2-BROMOMETHYL-4-FLUORO-BENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-BROMOMETHYL-4-FLUORO-BENZOATE(157652-28-3)
• EPA Substance Registry System: METHYL 2-BROMOMETHYL-4-FLUORO-BENZOATE(157652-28-3)

Safety Data

• Hazardous Substances Data: 157652-28-3(Hazardous Substances Data)

Usage

General Description

METHYL 2-BROMOMETHYL-4-FLUORO-BENZOATE is an organic compound with the chemical formula C9H8BrFO2. It is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various biologically active compounds. METHYL 2-BROMOMETHYL-4-FLUORO-BENZOATE is a bromine-substituted derivative of benzoic acid and is often used as a building block in the production of pharmaceuticals, agrochemicals, and other specialty chemicals. It is a white to off-white solid with a molecular weight of 239.06 g/mol and a melting point of 107-110°C. METHYL 2-BROMOMETHYL-4-FLUORO-BENZOATE is considered to be a versatile and valuable building block in organic synthesis due to its reactivity and functionality.

InChI:InChI=1/C9H8BrFO2/c1-13-9(12)8-3-2-7(11)4-6(8)5-10/h2-4H,5H2,1H3

Upstream product

• 21900-43-6 4-fluoro-2-methylbenzoyl chloride 
• 321-21-1 4-fluoro-2-methylbenzoic acid 
• 174403-69-1 4-fluoro-2-methyl benzoic acid methyl ester 

Downstream Products

• 1440519-88-9 5-fluoro-2-(4-methoxybenzyl)-2,3-dihydroisoindol-1-one 
• 1022984-21-9 5-fluoro-2-(4-dimethylaminophenyl)-2,3-dihydroisoindol-1-one 
• 199873-35-3 2-carbomethoxy-5-fluorobenzyl thiouronium hydrochloride 

Relevant articles and documents

MONO HALOGEN OR METHYL-SUBSTITUTED 5-HT2B ANTAGONISTS WITH INCREASED ACTIVITY

Disclose herein are mono halogen or methyl-substituted 5-HT 2B antagonist compounds, which have been found with increased binding activity to 5-HT 2B receptor due to the substitution of halogen or methyl, and the method of using the compounds of treating or preventing a disorder mediated by 5-HT 2B.

Conformational Studies and Atropisomerism Kinetics of the ALK Clinical Candidate Lorlatinib (PF-06463922) and Desmethyl Congeners

Lorlatinib (PF-06463922) is an ALK/ROS1 inhibitor and is in clinical trials for the treatment of ALK positive or ROS1 positive NSCLC (i.e. specific subsets of NSCLC). One of the laboratory objectives for this molecule indicated that it would be desirable

MACROCYCLIC DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES

The invention relates to compounds of formula (Φ) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.