15766-71-9

Usage

Uses

Used in Pharmaceutical Applications:
Sophoricoside is utilized as a therapeutic agent for its potential to inhibit the growth of cancer cells, protect against liver damage, and improve cardiovascular health. Its antioxidant and anti-inflammatory properties contribute to its effectiveness in these areas.
Used in Traditional Chinese Medicine:
Sophoricoside is employed in traditional Chinese medicine for its diverse medicinal properties, which include its ability to treat various ailments and promote overall health.
Used in Cosmetic Applications:
In the cosmetic industry, sophoricoside is used for its beneficial effects on skin health and its antioxidant properties. It can be incorporated into skincare products to enhance their protective and rejuvenating capabilities.
Used in Antioxidant Formulations:
Due to its potent antioxidant properties, sophoricoside is used in the development of antioxidant formulations that can help combat oxidative stress and protect cells from damage.
Used in Anti-Inflammatory Products:
Sophoricoside's anti-inflammatory characteristics make it a valuable component in products designed to reduce inflammation and alleviate pain or discomfort.

Upstream product

• 13410-15-6 (R)-8-hydroxy-6-methoxy-3-methylisochroman-1-one 
• 77-78-1 dimethyl sulfate 
• 190957-38-1 methyl 2,4-dimethoxy-6-(2-oxopropyl)-benzoate 
• 54901-09-6 3-(3,5-dimethoxyphenyl)propionic acid ethyl ester 
• 70901-60-9 (R)-6-hydroxymellein 
• 6512-31-8 2,4-dimethoxy-6-(2-oxopropyl)benzoic acid 
• 29584-64-3 ethyl 3,5-dimethoxycinnamate 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 125187-47-5 3-(3,5-dimethoxyphenyl)-1-propanal 
• 896448-37-6 1,3-dimethoxy-5-((2R)-hydroxypropyl)benzene 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 100117-90-6 2,4-dimethoxy-6-ξ-propenyl-benzoic acid 
• 13410-15-6 (R)-8-hydroxy-6-methoxy-3-methylisochroman-1-one 
• 17846-89-8 2-formyl-4,6-dimethoxy-benzoic acid 

Relevant academic research and scientific papers

Isolation and Structure Elucidation of a Novel Antimalarial Macrocyclic Polylactone, Menisporopsin A, from the Fungus Menisporopsis theobromae

An antimalarial macrocyclic polylactone, menisporopsin A (1), was isolated from a cell extract of the seed fungus Menisporopsis theobromae. The structure of 1 was elucidated on the basis of spectroscopic analysis and chemical transformations, with the absolute configuration established by application of the modified Mosher method and by using chiral HPLC. Menisporopsin A (1) possesses an unprecedented residue, 2,4-dihydroxy-6-(2,4-dihydroxy-n-pentyl)benzoic acid. This compound exhibited antimalarial activity, with an IC50 value of 4.0 μg mL -1, and antimycobacterial activity (MIC value of 50 μg mL -1).

Early Oxidative Transformations During the Biosynthesis of Terrein and Related Natural Products

The mycotoxin terrein is derived from the C10-precursor 6-hydroxymellein (6-HM) via an oxidative ring contraction. Although the corresponding biosynthetic gene cluster (BGC) has been identified, details of the enzymatic oxidative transformations are lacking. Combining heterologous expression and in vitro studies we show that the flavin-dependent monooxygenase (FMO) TerC catalyzes the initial oxidative decarboxylation of 6-HM. The reactive intermediate is further hydroxylated by the second FMO TerD to yield a highly oxygenated aromatic species, but further reconstitution of the pathway was hampered. A related BGC was identified in the marine-derived Roussoella sp. DLM33 and confirmed by heterologous expression. These studies demonstrate that the biosynthetic pathways of terrein and related (polychlorinated) congeners diverge after oxidative decarboxylation of the lactone precursor that is catalyzed by a conserved FMO and further indicate that early dehydration of the side chain is an essential step.

Asymmetric total synthesis of dihydroisocoumarins: 6-methoxymellein, kigelin and fusarentin 6, 7 dimethyl ether by employing proline catalysed asymmetric α-aminoxylation

A concise asymmetric total synthesis of dihydroisocoumarins such as 6-methoxymellein, kigelin and fusarentin 6,7-dimethyl ether in high enantiopurity have been achieved from non-chiral aldehydes by employing proline catalysed asymmetric α-aminoxylation reaction. The required stereochemistry of hydroxyl group have been generated by alternating L or D proline as a organocatalyst in α-aminoxylation step and lactone ring is assembled by oxa-Pictet-Spengler cyclisation reaction as the key steps.

Dihydroisocoumarins from fungi: Isolation, structure elucidation, circular dichroism and biological activity

Five known and three new dihydroisocoumarins were isolated from different fungi. The new isocoumarins are 5-chloro-6-hydroxymellein, 5- chloro-4,6-dihydroxymellein and 5,6-dihydroxymellein. The absolute configuration of these secondary metabolites was con