190957-38-1

Upstream product

• 186581-53-3 diazomethane 
• 6512-31-8 2,4-dimethoxy-6-(2-oxopropyl)benzoic acid 
• 6110-37-8 methyl 2,4-dimethoxy-6-methylbenzoate 
• 78191-00-1 N-Methoxy-N-methylacetamide 
• 3187-58-4 methyl orsellinate 

Downstream Products

• 15766-71-9 (3R)-3,4-dihydro-6,8-dimethoxy-3-methylisocoumarin 
• 1228467-53-5 methyl 2,4-dimethoxy-6-[(1E)-2-(trimethylsilyloxy)prop-1-en-1-yl]benzoate 

Relevant academic research and scientific papers

Dihydroisocoumarins from fungi: Isolation, structure elucidation, circular dichroism and biological activity

Five known and three new dihydroisocoumarins were isolated from different fungi. The new isocoumarins are 5-chloro-6-hydroxymellein, 5- chloro-4,6-dihydroxymellein and 5,6-dihydroxymellein. The absolute configuration of these secondary metabolites was con

Asymmetric synthesis of natural cis-dihydroarenediols using tetrahydroxynaphthalene reductase and its biosynthetic implications

Asymmetric reduction of hydroxynaphthoquinones to secondary metabolites, (3S,4R)-3,4,8- A nd (2S,4R)-2,4,8-trihydroxy-1-tetralone, a putative biosynthetic diketo intermediate and a probable natural analogue, (3S,4R)-7-acetyl-3,4,8-trihydroxy-6-methyl-3,4-

Total synthesis of (±)-cephalosol via silyl enol ether acylation

An efficient total synthesis of (±)-cephalosol is reported. Key steps are the acylation of a silyl enol ether with monomethyl oxalyl chloride and the subsequent acid-mediated ring closure to the isocoumarin structure. A chemoselective allylation and the conversion of the olefin into a methyl acetate were applied to install the γ-lactone moiety. Georg Thieme Verlag Stuttgart ? New York.

Process for the manufacture of hypoxyxylerone derivatives

The present invention relates to the total synthesis of hypoxyxylerone derivatives (formula I) and their biological activities. R1-R5 are as described in the description.