17846-89-8

Upstream product

• 100117-90-6 2,4-dimethoxy-6-ξ-propenyl-benzoic acid 
• 15766-71-9 (3R)-3,4-dihydro-6,8-dimethoxy-3-methylisocoumarin 
• 3465-69-8 5,7-dimethoxyphthalide 
• 39828-35-8 2,4-dimethoxybenzoyl chloride 
• 91-52-1 2,4 dimethoxybenzoic acid 
• 868756-10-9 N,N-diethyl 2-formyl-4,6-dimethoxybenzamide 
• 142601-55-6 N,N-diethyl-2,4-dimethoxybenzamide 
• 13410-15-6 (R)-8-hydroxy-6-methoxy-3-methylisochroman-1-one 
• 4670-17-1 3,5-dimethoxyphthalic anhydride 

Downstream Products

• 100117-90-6 2,4-dimethoxy-6-ξ-propenyl-benzoic acid 
• 1426562-43-7 2-hydroxy-4-methoxy-6-(2-(naphthalen-2-yl)ethyl)benzoic acid 
• 1452584-43-8 C₁₈H₁₉NO₃ 
• 17846-90-1 methyl 2-formyl-4,6-dimethoxybenzoate 
• 17846-92-3 cis-2-Propen-⁽¹⁾-yl-4.6-dimethoxy-benzoesaeuremethylester 
• 17924-91-3 2,4-Dimethoxy-6-(E-prop-1-enyl)benzoic acid 
• 17846-93-4 2-Propin-⁽¹⁾-yl-4.6-dimethoxy-benzoesaeure 
• 17947-63-6 2-Propin-⁽¹⁾-yl-4.6-dimethoxy-benzoesaeuremethylester 

Relevant academic research and scientific papers

Enantioselective addition of arylboronic acids to methyl 2-formylbenzoates by using a ruthenium/Me-BIPAM catalyst for synthesis of chiral 3-aryl-isobenzofuranones

Ruthenium/Me-BIPAM-catalyzed asymmetric addition of arylboronic acids to methyl 2-formylbenzoates afforded chiral 3-aryl-isobenzofuranones. [RuCl2(p-cymene)]2/Me-BIPAM and RuCl2(PPh3)3/Me-BIPAM catalyst systems tolerate a variety of functional groups and give high yields with high enantioselectivities.

Efficient synthesis of anacardic acid analogues and their antibacterial activities

Anacardic acid derivatives exhibit a broad range of biological activities. In this report, an efficient method for the synthesis of anacardic acid derivatives was explored, and a small set of salicylic acid variants synthesised retaining a constant hydrophobic element (a naphthyl tail). The naphthyl side chain was introduced via Wittig reaction and the aldehyde installed using directed ortho-metalation reaction of the substituted o-anisic acids. The failure of ortho-metalation using unprotected carboxylic acid group compelled us to use directed ortho-metalation in which a tertiary amide was used as a strong ortho-directing group. In the initial route, tertiary amide cleavage during final step was challenging, but cleaving the tertiary amide before Wittig reaction was beneficial. The Wittig reaction with protected carboxylic group (methyl ester) resulted in side-products whereas using sodium salt resulted in higher yields. The novel compounds were screened for antibacterial activity and cytotoxicity. Although substitution on the salicylic head group enhanced antibacterial activities they also enhanced cytotoxicity.

Probing the reactivity of o-phthalaldehydic acid/methyl ester: Synthesis of N-isoindolinones and 3-arylaminophthalides

A new method for the synthesis of N-substituted isoindolinones and 3-arylaminophthalides was developed through aza-Wittig/cyclisation. The reaction of o-phthalaldehydic acid methyl ester with benzylic, aromatic and aliphatic azides gave N-isoindolinones w