157758-38-8

Upstream product

• 157758-31-1 C₃₁H₅₀O₃Si₂ 
• 157758-37-7 (3S,4S,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-3-methyl-hept-1-en-4-ol 
• 157758-36-6 (S)-methyl 3-(tert-butyldimethylsilyloxy)-4-(tert-butyldiphenylsilyloxy)butanoate 
• 157758-30-0 (S)-3-((tert-butyldimethylsilyl)oxy)-4-((tert-butyldiphenylsilyl)oxy)butanal 
• 124655-05-6 (S)-methyl 4-(tert-butyldiphenylsilyloxy)-3-hydroxybutanoate 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 

Downstream Products

• 157758-29-7 (R)-2-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-oxirane 
• 157758-33-3 (S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-pyran-2-one 
• 157811-04-6 {(2R,6S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-2H-pyran-2-yl}-acetaldehyde 
• 157811-05-7 (E)-(S)-5-Hydroxy-6-{(2R,6S)-6-[(2S,3S)-2-methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-2H-pyran-2-yl}-2-methyl-hex-2-enoic acid methyl ester 
• 157758-32-2 (2S,4S,5S)-1-(tert-Butyl-diphenyl-silanyloxy)-4-methoxy-6-(4-methoxy-benzyloxy)-5-methyl-hexan-2-ol 
• 157758-34-4 (E)-(S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-{(2R,6S)-6-[(2S,3S)-2-methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-2H-pyran-2-yl}-2-methyl-hex-2-enoic acid methyl ester 
• 157758-39-9 Methanesulfonic acid (1S,3S,4S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-methoxy-5-(4-methoxy-benzyloxy)-4-methyl-pentyl ester 

Relevant academic research and scientific papers

A Convergent Approach to Swinholide A. Stereoselective Construction of the C3-C17 Fragment of Swinholide A

A strategy for a total synthesis of the cytotoxic dimeric macrolide swinholide A (1, Scheme 1) is outlined and a stereoselective construction of the suitably functionalized C3-C17 fragment 4, starting with building blocks 6, 7, 9 and 10 is described.