157809-85-3Relevant articles and documents
A novel approach for the synthesis of the peripheral benzodiazepine receptor ligand, PK11195
Stevenson, Louise,Pimlott, Sally L.,Sutherland, Andrew
, p. 7137 - 7139 (2008/03/11)
A new synthesis of the peripheral benzodiazepine receptor ligand, PK11195 has been developed in only six-steps using a Heck-type reaction and a Suzuki coupling to effect the key transformations. The flexibility of this new approach is demonstrated by the
Novel irreversible ligands specific for 'peripheral' type benzodiazepine receptors: (±)-, (+)-, and (-)-1-(2-chlorophenyl)-N-(1 methylpropyl)-N-(2-isothiocyanatoethyl)-3-isoquinolinecarboxamide and 1-(2-isothiocyanatoethyl)-7-chloro-1,3-dihydro-5-(4-chlor
Newman,Lueddens,Skolnick,Rice
, p. 1901 - 1905 (2007/10/02)
Novel ligands that bind irreversibly and selectively to 'peripheral' type benzodiazepine receptors (PBR) have been prepared. These compounds inhibits radiolabeled binding to PBR in the nanomolar range. The 2-isothiocyanatoethyl analogue of Ro 5-4864 (1-me