1579240-64-4

Basic information

• Product Name: methyl 2,3-(5-phenyl)-isoxazolo-olean-12-en-28-oate
• Synonyms: methyl 2,3-(5-phenyl)-isoxazolo-olean-12-en-28-oate
• CAS NO: 1579240-64-4
• Molecular Weight: 569.828
• Mol File: 1579240-64-4.mol

Chemical Properties

• CAS DataBase Reference: methyl 2,3-(5-phenyl)-isoxazolo-olean-12-en-28-oate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2,3-(5-phenyl)-isoxazolo-olean-12-en-28-oate(1579240-64-4)
• EPA Substance Registry System: methyl 2,3-(5-phenyl)-isoxazolo-olean-12-en-28-oate(1579240-64-4)

Safety Data

• Hazardous Substances Data: 1579240-64-4(Hazardous Substances Data)

Upstream product

• 508-02-1 Oleanolic acid 
• 170240-93-4 methyl-3-oxo-2-phenylmethylene-olean-12-ene-28-methyl ester 
• 1721-58-0 methyl 3-oxooleanolate 
• 1724-17-0 oleanolic acid methyl ester 

Relevant articles and documents

Synthesis of novel ring-A fused hybrids of oleanolic acid with capabilities to arrest cell cycle and induce apoptosis in breast cancer cells

Six novel oleanolic acid ring-A fused hybrids (5-10) have been synthesized by employing a four step protocol with the introduction of benzylidene functionality at C-2 as the key step. Their structures were established by high resolution NMR and Mass spectral data. The synthesized compounds have been screened against seven human cancer cell lines including ME-180 & HeLa (cervix), MCF-7, MDA-MB-453 & MDA-MB-231 (breast), PC-3 (prostate) and HT-29 (colon) using MTT assay. Most significantly, compound 10 showed potent activity against the three breast cancer cell lines. The IC50 value (10.60 μM) of compound 10 against MCF-7 found to be much lower than that of the standards and parent compound. Flow cytometric analysis reveals that compound 10 arrests cell cycle in S phase and induces apoptosis in MCF cells.2014 Elsevier Masson SAS. All rights reserved.