170240-93-4Relevant academic research and scientific papers
Synthesis of novel ring-A fused hybrids of oleanolic acid with capabilities to arrest cell cycle and induce apoptosis in breast cancer cells
Mallavadhani, Uppuluri Venkata,Vanga, Nagi Reddy,Jeengar, Manish Kumar,Naidu
, p. 398 - 404 (2014)
Six novel oleanolic acid ring-A fused hybrids (5-10) have been synthesized by employing a four step protocol with the introduction of benzylidene functionality at C-2 as the key step. Their structures were established by high resolution NMR and Mass spectral data. The synthesized compounds have been screened against seven human cancer cell lines including ME-180 & HeLa (cervix), MCF-7, MDA-MB-453 & MDA-MB-231 (breast), PC-3 (prostate) and HT-29 (colon) using MTT assay. Most significantly, compound 10 showed potent activity against the three breast cancer cell lines. The IC50 value (10.60 μM) of compound 10 against MCF-7 found to be much lower than that of the standards and parent compound. Flow cytometric analysis reveals that compound 10 arrests cell cycle in S phase and induces apoptosis in MCF cells.2014 Elsevier Masson SAS. All rights reserved.
Triterpenoids. Part 9. Structure Elucidation of a New Sodium Dichromate Oxidation Product of Methyl Oleanolate and some of its Derivatives
Zaprutko, L.
, p. 1003 - 1012 (2007/10/02)
Methyl oleanolate 1a was oxidized to methyl 2,3-dinor-1,4-lactone-9α-hydroxy-11-oxo-12-oleanen-28-oate (2) by sodium dichromate in refluxing acetic acid.Compound 2 upon treatment with zinc in acetic acid gives methyl 2,3-dinor-1,4-lactone-9(11),12-oleandi
